Cargando…
Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis
This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clinically or genetically diagnosed) on craniofacial cephalometric characteristics (CCC) to combine publicly available scientific information while also improving the validity of primary study findings. A co...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983770/ https://www.ncbi.nlm.nih.gov/pubmed/35383244 http://dx.doi.org/10.1038/s41598-022-09764-y |
_version_ | 1784682030995341312 |
---|---|
author | Alam, Mohammad Khursheed Alfawzan, Ahmed Ali Srivastava, Kumar Chandan Shrivastava, Deepti Ganji, Kiran Kumar Manay, Srinivas Munisekhar |
author_facet | Alam, Mohammad Khursheed Alfawzan, Ahmed Ali Srivastava, Kumar Chandan Shrivastava, Deepti Ganji, Kiran Kumar Manay, Srinivas Munisekhar |
author_sort | Alam, Mohammad Khursheed |
collection | PubMed |
description | This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clinically or genetically diagnosed) on craniofacial cephalometric characteristics (CCC) to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, an article published between 1st January 2000 to October 17th, 2021. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to carry out this systematic review. We used the PECO system to classify people with AS based on whether or not they had distinctive CCC compared to the non-AS population. Following are some examples of how PECO has been used: People with AS are labeled P; clinical or genetic diagnosis of AS is labeled E; individuals without AS are labeled C; CCC of AS are labeled O. Using the Newcastle–Ottawa Quality-Assessment-Scale, independent reviewers assessed the articles' methodological quality and extracted data. 13 studies were included in the systematic review. 8 out of 13 studies were score 7–8 in NOS scale, which indicated that most of the studies were medium to high qualities. Six case–control studies were analyzed for meta-analysis. Due to the wide range of variability in CCC, we were only able to include data from at least three previous studies. There was a statistically significant difference in N-S-PP (I(2): 76.56%; P = 0.014; CI 1.27 to − 0.28) and Greater wing angle (I(2): 79.07%; P = 0.008; CI 3.07–1.17) between AS and control subjects. Cleft palate, anterior open bite, crowding in the upper jaw, and hypodontia occurred more frequently among AS patients. Significant shortening of the mandibular width, height and length is the most reported feature in AS patients. CT scans can help patients with AS decide whether to pursue orthodontic treatment alone or to have their mouth surgically expanded. The role of well-informed orthodontic and maxillofacial practitioners is critical in preventing and rehabilitating oral health issues. |
format | Online Article Text |
id | pubmed-8983770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89837702022-04-06 Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis Alam, Mohammad Khursheed Alfawzan, Ahmed Ali Srivastava, Kumar Chandan Shrivastava, Deepti Ganji, Kiran Kumar Manay, Srinivas Munisekhar Sci Rep Article This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clinically or genetically diagnosed) on craniofacial cephalometric characteristics (CCC) to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, an article published between 1st January 2000 to October 17th, 2021. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to carry out this systematic review. We used the PECO system to classify people with AS based on whether or not they had distinctive CCC compared to the non-AS population. Following are some examples of how PECO has been used: People with AS are labeled P; clinical or genetic diagnosis of AS is labeled E; individuals without AS are labeled C; CCC of AS are labeled O. Using the Newcastle–Ottawa Quality-Assessment-Scale, independent reviewers assessed the articles' methodological quality and extracted data. 13 studies were included in the systematic review. 8 out of 13 studies were score 7–8 in NOS scale, which indicated that most of the studies were medium to high qualities. Six case–control studies were analyzed for meta-analysis. Due to the wide range of variability in CCC, we were only able to include data from at least three previous studies. There was a statistically significant difference in N-S-PP (I(2): 76.56%; P = 0.014; CI 1.27 to − 0.28) and Greater wing angle (I(2): 79.07%; P = 0.008; CI 3.07–1.17) between AS and control subjects. Cleft palate, anterior open bite, crowding in the upper jaw, and hypodontia occurred more frequently among AS patients. Significant shortening of the mandibular width, height and length is the most reported feature in AS patients. CT scans can help patients with AS decide whether to pursue orthodontic treatment alone or to have their mouth surgically expanded. The role of well-informed orthodontic and maxillofacial practitioners is critical in preventing and rehabilitating oral health issues. Nature Publishing Group UK 2022-04-05 /pmc/articles/PMC8983770/ /pubmed/35383244 http://dx.doi.org/10.1038/s41598-022-09764-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Alam, Mohammad Khursheed Alfawzan, Ahmed Ali Srivastava, Kumar Chandan Shrivastava, Deepti Ganji, Kiran Kumar Manay, Srinivas Munisekhar Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title | Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title_full | Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title_fullStr | Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title_full_unstemmed | Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title_short | Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis |
title_sort | craniofacial morphology in apert syndrome: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983770/ https://www.ncbi.nlm.nih.gov/pubmed/35383244 http://dx.doi.org/10.1038/s41598-022-09764-y |
work_keys_str_mv | AT alammohammadkhursheed craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis AT alfawzanahmedali craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis AT srivastavakumarchandan craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis AT shrivastavadeepti craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis AT ganjikirankumar craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis AT manaysrinivasmunisekhar craniofacialmorphologyinapertsyndromeasystematicreviewandmetaanalysis |