Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation

BiP co-chaperones ERdj4, ERdj5, and GRP170 associate in cells with peptides predicted to be aggregation prone. Here, extending these findings to a full-length protein, we examine two Interstitial Lung Disease-associated mutants (ILD) of surfactant protein C (SP-C). The TANGO algorithm, which identif...

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Detalles Bibliográficos
Autores principales: Pobre-Piza, Kristine F. R., Mann, Melissa J., Flory, Ashley R., Hendershot, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983781/
https://www.ncbi.nlm.nih.gov/pubmed/35383173
http://dx.doi.org/10.1038/s41467-022-29478-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983781/
https://www.ncbi.nlm.nih.gov/pubmed/35383173
http://dx.doi.org/10.1038/s41467-022-29478-z

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