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Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help i...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983845/ https://www.ncbi.nlm.nih.gov/pubmed/35401250 http://dx.doi.org/10.3389/fpsyt.2022.859768 |
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author | Becerril-Villanueva, Enrique Olvera-Alvarez, María Irma Alvarez-Herrera, Samantha Maldonado-García, Jose Luis López-Torres, Adolfo Ramírez-Marroquín, Oscar Abelardo González-Ruiz, Octavio Nogueira-Fernández, José Manuel Mendoza-Contreras, José Manuel Sánchez-García, Héctor Omar José-Alfallo, José Antonio Valencia Baños, Atenodoro Torres-Serrano, Ana Berta Jiménez-Genchi, Janeth Mendieta-Cabrera, Danelia Pérez-Sánchez, Gilberto Pavón, Lenin |
author_facet | Becerril-Villanueva, Enrique Olvera-Alvarez, María Irma Alvarez-Herrera, Samantha Maldonado-García, Jose Luis López-Torres, Adolfo Ramírez-Marroquín, Oscar Abelardo González-Ruiz, Octavio Nogueira-Fernández, José Manuel Mendoza-Contreras, José Manuel Sánchez-García, Héctor Omar José-Alfallo, José Antonio Valencia Baños, Atenodoro Torres-Serrano, Ana Berta Jiménez-Genchi, Janeth Mendieta-Cabrera, Danelia Pérez-Sánchez, Gilberto Pavón, Lenin |
author_sort | Becerril-Villanueva, Enrique |
collection | PubMed |
description | Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health. |
format | Online Article Text |
id | pubmed-8983845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89838452022-04-07 Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach Becerril-Villanueva, Enrique Olvera-Alvarez, María Irma Alvarez-Herrera, Samantha Maldonado-García, Jose Luis López-Torres, Adolfo Ramírez-Marroquín, Oscar Abelardo González-Ruiz, Octavio Nogueira-Fernández, José Manuel Mendoza-Contreras, José Manuel Sánchez-García, Héctor Omar José-Alfallo, José Antonio Valencia Baños, Atenodoro Torres-Serrano, Ana Berta Jiménez-Genchi, Janeth Mendieta-Cabrera, Danelia Pérez-Sánchez, Gilberto Pavón, Lenin Front Psychiatry Psychiatry Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8983845/ /pubmed/35401250 http://dx.doi.org/10.3389/fpsyt.2022.859768 Text en Copyright © 2022 Becerril-Villanueva, Olvera-Alvarez, Alvarez-Herrera, Maldonado-García, López-Torres, Ramírez-Marroquín, González-Ruiz, Nogueira-Fernández, Mendoza-Contreras, Sánchez-García, José-Alfallo, Valencia Baños, Torres-Serrano, Jiménez-Genchi, Mendieta-Cabrera, Pérez-Sánchez and Pavón. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Becerril-Villanueva, Enrique Olvera-Alvarez, María Irma Alvarez-Herrera, Samantha Maldonado-García, Jose Luis López-Torres, Adolfo Ramírez-Marroquín, Oscar Abelardo González-Ruiz, Octavio Nogueira-Fernández, José Manuel Mendoza-Contreras, José Manuel Sánchez-García, Héctor Omar José-Alfallo, José Antonio Valencia Baños, Atenodoro Torres-Serrano, Ana Berta Jiménez-Genchi, Janeth Mendieta-Cabrera, Danelia Pérez-Sánchez, Gilberto Pavón, Lenin Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title | Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title_full | Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title_fullStr | Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title_full_unstemmed | Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title_short | Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach |
title_sort | screening of sert and p11 mrna levels in airline pilots: a translational approach |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983845/ https://www.ncbi.nlm.nih.gov/pubmed/35401250 http://dx.doi.org/10.3389/fpsyt.2022.859768 |
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