Cargando…

Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach

Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help i...

Descripción completa

Detalles Bibliográficos
Autores principales: Becerril-Villanueva, Enrique, Olvera-Alvarez, María Irma, Alvarez-Herrera, Samantha, Maldonado-García, Jose Luis, López-Torres, Adolfo, Ramírez-Marroquín, Oscar Abelardo, González-Ruiz, Octavio, Nogueira-Fernández, José Manuel, Mendoza-Contreras, José Manuel, Sánchez-García, Héctor Omar, José-Alfallo, José Antonio, Valencia Baños, Atenodoro, Torres-Serrano, Ana Berta, Jiménez-Genchi, Janeth, Mendieta-Cabrera, Danelia, Pérez-Sánchez, Gilberto, Pavón, Lenin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983845/
https://www.ncbi.nlm.nih.gov/pubmed/35401250
http://dx.doi.org/10.3389/fpsyt.2022.859768
_version_ 1784682046458691584
author Becerril-Villanueva, Enrique
Olvera-Alvarez, María Irma
Alvarez-Herrera, Samantha
Maldonado-García, Jose Luis
López-Torres, Adolfo
Ramírez-Marroquín, Oscar Abelardo
González-Ruiz, Octavio
Nogueira-Fernández, José Manuel
Mendoza-Contreras, José Manuel
Sánchez-García, Héctor Omar
José-Alfallo, José Antonio
Valencia Baños, Atenodoro
Torres-Serrano, Ana Berta
Jiménez-Genchi, Janeth
Mendieta-Cabrera, Danelia
Pérez-Sánchez, Gilberto
Pavón, Lenin
author_facet Becerril-Villanueva, Enrique
Olvera-Alvarez, María Irma
Alvarez-Herrera, Samantha
Maldonado-García, Jose Luis
López-Torres, Adolfo
Ramírez-Marroquín, Oscar Abelardo
González-Ruiz, Octavio
Nogueira-Fernández, José Manuel
Mendoza-Contreras, José Manuel
Sánchez-García, Héctor Omar
José-Alfallo, José Antonio
Valencia Baños, Atenodoro
Torres-Serrano, Ana Berta
Jiménez-Genchi, Janeth
Mendieta-Cabrera, Danelia
Pérez-Sánchez, Gilberto
Pavón, Lenin
author_sort Becerril-Villanueva, Enrique
collection PubMed
description Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health.
format Online
Article
Text
id pubmed-8983845
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89838452022-04-07 Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach Becerril-Villanueva, Enrique Olvera-Alvarez, María Irma Alvarez-Herrera, Samantha Maldonado-García, Jose Luis López-Torres, Adolfo Ramírez-Marroquín, Oscar Abelardo González-Ruiz, Octavio Nogueira-Fernández, José Manuel Mendoza-Contreras, José Manuel Sánchez-García, Héctor Omar José-Alfallo, José Antonio Valencia Baños, Atenodoro Torres-Serrano, Ana Berta Jiménez-Genchi, Janeth Mendieta-Cabrera, Danelia Pérez-Sánchez, Gilberto Pavón, Lenin Front Psychiatry Psychiatry Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8983845/ /pubmed/35401250 http://dx.doi.org/10.3389/fpsyt.2022.859768 Text en Copyright © 2022 Becerril-Villanueva, Olvera-Alvarez, Alvarez-Herrera, Maldonado-García, López-Torres, Ramírez-Marroquín, González-Ruiz, Nogueira-Fernández, Mendoza-Contreras, Sánchez-García, José-Alfallo, Valencia Baños, Torres-Serrano, Jiménez-Genchi, Mendieta-Cabrera, Pérez-Sánchez and Pavón. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Becerril-Villanueva, Enrique
Olvera-Alvarez, María Irma
Alvarez-Herrera, Samantha
Maldonado-García, Jose Luis
López-Torres, Adolfo
Ramírez-Marroquín, Oscar Abelardo
González-Ruiz, Octavio
Nogueira-Fernández, José Manuel
Mendoza-Contreras, José Manuel
Sánchez-García, Héctor Omar
José-Alfallo, José Antonio
Valencia Baños, Atenodoro
Torres-Serrano, Ana Berta
Jiménez-Genchi, Janeth
Mendieta-Cabrera, Danelia
Pérez-Sánchez, Gilberto
Pavón, Lenin
Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title_full Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title_fullStr Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title_full_unstemmed Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title_short Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach
title_sort screening of sert and p11 mrna levels in airline pilots: a translational approach
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983845/
https://www.ncbi.nlm.nih.gov/pubmed/35401250
http://dx.doi.org/10.3389/fpsyt.2022.859768
work_keys_str_mv AT becerrilvillanuevaenrique screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT olveraalvarezmariairma screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT alvarezherrerasamantha screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT maldonadogarciajoseluis screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT lopeztorresadolfo screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT ramirezmarroquinoscarabelardo screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT gonzalezruizoctavio screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT nogueirafernandezjosemanuel screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT mendozacontrerasjosemanuel screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT sanchezgarciahectoromar screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT josealfallojoseantonio screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT valenciabanosatenodoro screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT torresserranoanaberta screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT jimenezgenchijaneth screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT mendietacabreradanelia screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT perezsanchezgilberto screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach
AT pavonlenin screeningofsertandp11mrnalevelsinairlinepilotsatranslationalapproach