The Role of Interleukin-6 Family Members in Cardiovascular Diseases

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multipl...

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Autores principales: Feng, Yongqi, Ye, Di, Wang, Zhen, Pan, Heng, Lu, Xiyi, Wang, Menglong, Xu, Yao, Yu, Junping, Zhang, Jishou, Zhao, Mengmeng, Xu, Shuwan, Pan, Wei, Yin, Zheng, Ye, Jing, Wan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983865/
https://www.ncbi.nlm.nih.gov/pubmed/35402550
http://dx.doi.org/10.3389/fcvm.2022.818890
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author Feng, Yongqi
Ye, Di
Wang, Zhen
Pan, Heng
Lu, Xiyi
Wang, Menglong
Xu, Yao
Yu, Junping
Zhang, Jishou
Zhao, Mengmeng
Xu, Shuwan
Pan, Wei
Yin, Zheng
Ye, Jing
Wan, Jun
author_facet Feng, Yongqi
Ye, Di
Wang, Zhen
Pan, Heng
Lu, Xiyi
Wang, Menglong
Xu, Yao
Yu, Junping
Zhang, Jishou
Zhao, Mengmeng
Xu, Shuwan
Pan, Wei
Yin, Zheng
Ye, Jing
Wan, Jun
author_sort Feng, Yongqi
collection PubMed
description Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment.
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spelling pubmed-89838652022-04-07 The Role of Interleukin-6 Family Members in Cardiovascular Diseases Feng, Yongqi Ye, Di Wang, Zhen Pan, Heng Lu, Xiyi Wang, Menglong Xu, Yao Yu, Junping Zhang, Jishou Zhao, Mengmeng Xu, Shuwan Pan, Wei Yin, Zheng Ye, Jing Wan, Jun Front Cardiovasc Med Cardiovascular Medicine Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8983865/ /pubmed/35402550 http://dx.doi.org/10.3389/fcvm.2022.818890 Text en Copyright © 2022 Feng, Ye, Wang, Pan, Lu, Wang, Xu, Yu, Zhang, Zhao, Xu, Pan, Yin, Ye and Wan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Feng, Yongqi
Ye, Di
Wang, Zhen
Pan, Heng
Lu, Xiyi
Wang, Menglong
Xu, Yao
Yu, Junping
Zhang, Jishou
Zhao, Mengmeng
Xu, Shuwan
Pan, Wei
Yin, Zheng
Ye, Jing
Wan, Jun
The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title_full The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title_fullStr The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title_full_unstemmed The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title_short The Role of Interleukin-6 Family Members in Cardiovascular Diseases
title_sort role of interleukin-6 family members in cardiovascular diseases
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983865/
https://www.ncbi.nlm.nih.gov/pubmed/35402550
http://dx.doi.org/10.3389/fcvm.2022.818890
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