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Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease

OBJECTIVE: Kawasaki disease (KD) is the most common form of pediatric vasculitis. We evaluated the influence of KD on cardiopulmonary function and analyzed the echocardiographic findings of patients with KD through serial follow-ups from childhood to adolescence. METHODS: This was a retrospective st...

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Autores principales: Lin, Ko-Long, Liou, I-Hsiu, Chen, Guan-Bo, Sun, Shu-Fen, Weng, Ken-Pen, Li, Chien-Hui, Tuan, Sheng-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983877/
https://www.ncbi.nlm.nih.gov/pubmed/35402363
http://dx.doi.org/10.3389/fped.2022.847343
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author Lin, Ko-Long
Liou, I-Hsiu
Chen, Guan-Bo
Sun, Shu-Fen
Weng, Ken-Pen
Li, Chien-Hui
Tuan, Sheng-Hui
author_facet Lin, Ko-Long
Liou, I-Hsiu
Chen, Guan-Bo
Sun, Shu-Fen
Weng, Ken-Pen
Li, Chien-Hui
Tuan, Sheng-Hui
author_sort Lin, Ko-Long
collection PubMed
description OBJECTIVE: Kawasaki disease (KD) is the most common form of pediatric vasculitis. We evaluated the influence of KD on cardiopulmonary function and analyzed the echocardiographic findings of patients with KD through serial follow-ups from childhood to adolescence. METHODS: This was a retrospective study. We recruited patients with KD after the acute stage who underwent at least two (with >1-year interval between visits) cardiopulmonary exercise testing (CPET) and echocardiographic examinations in the last 10 years. Cardiopulmonary function was determined through CPET on a treadmill. The maximum Z score (Max-Z) of the proximal left anterior descending coronary artery or right coronary artery was determined using echocardiography. Healthy peers matched for age, sex, and body mass index with serial CPET and echocardiographic data were recruited as a control group. RESULTS: Each group consisted of 30 participants with comparable basic characteristics. No significant differences in the variables of the first CPET were observed between the two groups. In the final CPET, the control group had a higher percentage of measured oxygen consumption (Vo(2)) at the anaerobic threshold (AT) to the predicted peak Vo(2) (p = 0.016), higher percentage of measured peak Vo(2) to the predicted peak Vo(2) (p = 0.0004), and higher Vo(2) at AT (p < 0.0001) than those of the KD group. No significant difference in the percentage of distribution of Max-Z was observed between the first and final echocardiographic examinations. CONCLUSIONS: Children with a history of KD had comparable exercise capacity to their healthy peers. However, in the follow-up, the aerobic metabolism and peak exercise load capacities of adolescents with KD were significantly lower than those of control adolescents.
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spelling pubmed-89838772022-04-07 Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease Lin, Ko-Long Liou, I-Hsiu Chen, Guan-Bo Sun, Shu-Fen Weng, Ken-Pen Li, Chien-Hui Tuan, Sheng-Hui Front Pediatr Pediatrics OBJECTIVE: Kawasaki disease (KD) is the most common form of pediatric vasculitis. We evaluated the influence of KD on cardiopulmonary function and analyzed the echocardiographic findings of patients with KD through serial follow-ups from childhood to adolescence. METHODS: This was a retrospective study. We recruited patients with KD after the acute stage who underwent at least two (with >1-year interval between visits) cardiopulmonary exercise testing (CPET) and echocardiographic examinations in the last 10 years. Cardiopulmonary function was determined through CPET on a treadmill. The maximum Z score (Max-Z) of the proximal left anterior descending coronary artery or right coronary artery was determined using echocardiography. Healthy peers matched for age, sex, and body mass index with serial CPET and echocardiographic data were recruited as a control group. RESULTS: Each group consisted of 30 participants with comparable basic characteristics. No significant differences in the variables of the first CPET were observed between the two groups. In the final CPET, the control group had a higher percentage of measured oxygen consumption (Vo(2)) at the anaerobic threshold (AT) to the predicted peak Vo(2) (p = 0.016), higher percentage of measured peak Vo(2) to the predicted peak Vo(2) (p = 0.0004), and higher Vo(2) at AT (p < 0.0001) than those of the KD group. No significant difference in the percentage of distribution of Max-Z was observed between the first and final echocardiographic examinations. CONCLUSIONS: Children with a history of KD had comparable exercise capacity to their healthy peers. However, in the follow-up, the aerobic metabolism and peak exercise load capacities of adolescents with KD were significantly lower than those of control adolescents. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8983877/ /pubmed/35402363 http://dx.doi.org/10.3389/fped.2022.847343 Text en Copyright © 2022 Lin, Liou, Chen, Sun, Weng, Li and Tuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Lin, Ko-Long
Liou, I-Hsiu
Chen, Guan-Bo
Sun, Shu-Fen
Weng, Ken-Pen
Li, Chien-Hui
Tuan, Sheng-Hui
Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title_full Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title_fullStr Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title_full_unstemmed Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title_short Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease
title_sort serial exercise testing and echocardiography findings of patients with kawasaki disease
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983877/
https://www.ncbi.nlm.nih.gov/pubmed/35402363
http://dx.doi.org/10.3389/fped.2022.847343
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