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The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020

BACKGROUND: In tropical Africa, data about influenza‐associated illness burden are needed to assess potential benefits of influenza vaccination among pregnant women. We estimated the incidence of influenza among pregnant women and their infants in Siaya County, Kenya. METHODS: We enrolled women at &...

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Autores principales: Otieno, Nancy A., Nyawanda, Bryan O., McMorrow, Meredith, Oneko, Martina, Omollo, Daniel, Lidechi, Shirley, Widdowson, Marc‐Alain, Flannery, Brendan, Chaves, Sandra S., Azziz‐Baumgartner, Eduardo, Emukule, Gideon O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983887/
https://www.ncbi.nlm.nih.gov/pubmed/35066993
http://dx.doi.org/10.1111/irv.12950
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author Otieno, Nancy A.
Nyawanda, Bryan O.
McMorrow, Meredith
Oneko, Martina
Omollo, Daniel
Lidechi, Shirley
Widdowson, Marc‐Alain
Flannery, Brendan
Chaves, Sandra S.
Azziz‐Baumgartner, Eduardo
Emukule, Gideon O.
author_facet Otieno, Nancy A.
Nyawanda, Bryan O.
McMorrow, Meredith
Oneko, Martina
Omollo, Daniel
Lidechi, Shirley
Widdowson, Marc‐Alain
Flannery, Brendan
Chaves, Sandra S.
Azziz‐Baumgartner, Eduardo
Emukule, Gideon O.
author_sort Otieno, Nancy A.
collection PubMed
description BACKGROUND: In tropical Africa, data about influenza‐associated illness burden are needed to assess potential benefits of influenza vaccination among pregnant women. We estimated the incidence of influenza among pregnant women and their infants in Siaya County, Kenya. METHODS: We enrolled women at <31 weeks of gestation and conducted weekly follow‐up until 6‐month postpartum to identify acute respiratory illnesses (ARIs). We defined ARI among mothers as reported cough, rhinorrhoea or sore throat and among infants as maternal‐reported cough, difficulty breathing, rhinorrhoea or clinician diagnosis of respiratory illness. We collected nasal/nasopharyngeal and oropharyngeal swabs from mothers/infants with ARI and tested for influenza A and B using molecular assays. We calculated antenatal incidence of laboratory‐confirmed influenza among mothers and postnatal incidence among mothers and infants. RESULTS: During June 2015 to May 2020, we analysed data from 3,026 pregnant women at a median gestational age of 16 weeks (interquartile range [IQR], 13, 18) and followed 2,550 infants. Incidence of laboratory‐confirmed influenza during pregnancy (10.3 episodes per 1,000 person‐months [95% confidence interval {CI} 8.6–11.8]) was twofold higher than in the postpartum period (4.0 [95% CI 2.6–5.5]; p < 0.01). Incidence was significantly higher among human immunodeficiency virus (HIV)‐infected pregnant women (15.6 [95% CI 11.0–20.6] vs. 9.1 [95% CI 7.5–10.8]; p < 0.01). Incidence among young infants was 4.4 (95% CI 3.0–5.9) and similar among HIV‐exposed and HIV‐unexposed infants. CONCLUSION: Our findings suggest a substantial burden of influenza illnesses during pregnancy, with a higher burden among HIV‐infected mothers. Kenyan authorities should consider the value of vaccinating pregnant women, especially if HIV infected.
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spelling pubmed-89838872022-05-01 The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020 Otieno, Nancy A. Nyawanda, Bryan O. McMorrow, Meredith Oneko, Martina Omollo, Daniel Lidechi, Shirley Widdowson, Marc‐Alain Flannery, Brendan Chaves, Sandra S. Azziz‐Baumgartner, Eduardo Emukule, Gideon O. Influenza Other Respir Viruses Original Articles BACKGROUND: In tropical Africa, data about influenza‐associated illness burden are needed to assess potential benefits of influenza vaccination among pregnant women. We estimated the incidence of influenza among pregnant women and their infants in Siaya County, Kenya. METHODS: We enrolled women at <31 weeks of gestation and conducted weekly follow‐up until 6‐month postpartum to identify acute respiratory illnesses (ARIs). We defined ARI among mothers as reported cough, rhinorrhoea or sore throat and among infants as maternal‐reported cough, difficulty breathing, rhinorrhoea or clinician diagnosis of respiratory illness. We collected nasal/nasopharyngeal and oropharyngeal swabs from mothers/infants with ARI and tested for influenza A and B using molecular assays. We calculated antenatal incidence of laboratory‐confirmed influenza among mothers and postnatal incidence among mothers and infants. RESULTS: During June 2015 to May 2020, we analysed data from 3,026 pregnant women at a median gestational age of 16 weeks (interquartile range [IQR], 13, 18) and followed 2,550 infants. Incidence of laboratory‐confirmed influenza during pregnancy (10.3 episodes per 1,000 person‐months [95% confidence interval {CI} 8.6–11.8]) was twofold higher than in the postpartum period (4.0 [95% CI 2.6–5.5]; p < 0.01). Incidence was significantly higher among human immunodeficiency virus (HIV)‐infected pregnant women (15.6 [95% CI 11.0–20.6] vs. 9.1 [95% CI 7.5–10.8]; p < 0.01). Incidence among young infants was 4.4 (95% CI 3.0–5.9) and similar among HIV‐exposed and HIV‐unexposed infants. CONCLUSION: Our findings suggest a substantial burden of influenza illnesses during pregnancy, with a higher burden among HIV‐infected mothers. Kenyan authorities should consider the value of vaccinating pregnant women, especially if HIV infected. John Wiley and Sons Inc. 2022-01-23 2022-05 /pmc/articles/PMC8983887/ /pubmed/35066993 http://dx.doi.org/10.1111/irv.12950 Text en © 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Otieno, Nancy A.
Nyawanda, Bryan O.
McMorrow, Meredith
Oneko, Martina
Omollo, Daniel
Lidechi, Shirley
Widdowson, Marc‐Alain
Flannery, Brendan
Chaves, Sandra S.
Azziz‐Baumgartner, Eduardo
Emukule, Gideon O.
The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title_full The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title_fullStr The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title_full_unstemmed The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title_short The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
title_sort burden of influenza among kenyan pregnant and postpartum women and their infants, 2015–2020
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983887/
https://www.ncbi.nlm.nih.gov/pubmed/35066993
http://dx.doi.org/10.1111/irv.12950
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