Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults

Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50–80 with and without type 2 diabetes mellitus. Serologic response to influenza...

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Autores principales: Spencer, Sarah, Chung, Jessie R., Belongia, Edward A., Sundaram, Maria, Meece, Jennifer, Coleman, Laura A., Zimmerman, Richard K., Nowalk, Mary Patricia, Moehling Geffel, Krissy, Ross, Ted, Carter, Chalise E., Shay, David, Levine, Min, Liepkalns, Justine, Kim, Jin Hyang, Sambhara, Suryaprakash, Thompson, Mark G., Flannery, Brendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983908/
https://www.ncbi.nlm.nih.gov/pubmed/34859584
http://dx.doi.org/10.1111/irv.12933
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author Spencer, Sarah
Chung, Jessie R.
Belongia, Edward A.
Sundaram, Maria
Meece, Jennifer
Coleman, Laura A.
Zimmerman, Richard K.
Nowalk, Mary Patricia
Moehling Geffel, Krissy
Ross, Ted
Carter, Chalise E.
Shay, David
Levine, Min
Liepkalns, Justine
Kim, Jin Hyang
Sambhara, Suryaprakash
Thompson, Mark G.
Flannery, Brendan
author_facet Spencer, Sarah
Chung, Jessie R.
Belongia, Edward A.
Sundaram, Maria
Meece, Jennifer
Coleman, Laura A.
Zimmerman, Richard K.
Nowalk, Mary Patricia
Moehling Geffel, Krissy
Ross, Ted
Carter, Chalise E.
Shay, David
Levine, Min
Liepkalns, Justine
Kim, Jin Hyang
Sambhara, Suryaprakash
Thompson, Mark G.
Flannery, Brendan
author_sort Spencer, Sarah
collection PubMed
description Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50–80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold‐increases in antibody titer occurred among participants with lower pre‐vaccination antibody titers. Waning of antibody titers was not influenced by diabetes status.
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spelling pubmed-89839082022-05-01 Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults Spencer, Sarah Chung, Jessie R. Belongia, Edward A. Sundaram, Maria Meece, Jennifer Coleman, Laura A. Zimmerman, Richard K. Nowalk, Mary Patricia Moehling Geffel, Krissy Ross, Ted Carter, Chalise E. Shay, David Levine, Min Liepkalns, Justine Kim, Jin Hyang Sambhara, Suryaprakash Thompson, Mark G. Flannery, Brendan Influenza Other Respir Viruses Original Articles Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50–80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold‐increases in antibody titer occurred among participants with lower pre‐vaccination antibody titers. Waning of antibody titers was not influenced by diabetes status. John Wiley and Sons Inc. 2021-12-03 2022-05 /pmc/articles/PMC8983908/ /pubmed/34859584 http://dx.doi.org/10.1111/irv.12933 Text en Published 2021. This article is a U.S. Government work and is in the public domain in the USA. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Spencer, Sarah
Chung, Jessie R.
Belongia, Edward A.
Sundaram, Maria
Meece, Jennifer
Coleman, Laura A.
Zimmerman, Richard K.
Nowalk, Mary Patricia
Moehling Geffel, Krissy
Ross, Ted
Carter, Chalise E.
Shay, David
Levine, Min
Liepkalns, Justine
Kim, Jin Hyang
Sambhara, Suryaprakash
Thompson, Mark G.
Flannery, Brendan
Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title_full Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title_fullStr Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title_full_unstemmed Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title_short Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
title_sort impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983908/
https://www.ncbi.nlm.nih.gov/pubmed/34859584
http://dx.doi.org/10.1111/irv.12933
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