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Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease

Coronary artery lesions (CALs) are severe complications of Kawasaki disease (KD), resulting in stenosis and thrombogenesis. Metabolomic profiling of patients’ plasma could assist in elucidating the pathogenesis of CALs and identifying diagnostic biomarkers, which are imperative for clinical treatmen...

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Autores principales: Zhu, Qiongjun, Dong, Qianqian, Wang, Xuliang, Xia, Tianhe, Fu, Yu, Wang, Qiaoyu, Wu, Rongzhou, Wu, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983937/
https://www.ncbi.nlm.nih.gov/pubmed/35401162
http://dx.doi.org/10.3389/fphar.2022.809157
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author Zhu, Qiongjun
Dong, Qianqian
Wang, Xuliang
Xia, Tianhe
Fu, Yu
Wang, Qiaoyu
Wu, Rongzhou
Wu, Tingting
author_facet Zhu, Qiongjun
Dong, Qianqian
Wang, Xuliang
Xia, Tianhe
Fu, Yu
Wang, Qiaoyu
Wu, Rongzhou
Wu, Tingting
author_sort Zhu, Qiongjun
collection PubMed
description Coronary artery lesions (CALs) are severe complications of Kawasaki disease (KD), resulting in stenosis and thrombogenesis. Metabolomic profiling of patients’ plasma could assist in elucidating the pathogenesis of CALs and identifying diagnostic biomarkers, which are imperative for clinical treatment. The metabolic profiles between KD patients with CALs and without CALs (non-coronary artery lesion, or NCAL, group) indicated the most significantly differentially expressed metabolite, palmitic acid (PA), showed the most massive fold change at 9.879. Furthermore, PA was proven to aggravate endothelial cellular senescence by increasing the generation of reactive oxygen species (ROS) in KD, and those two phenotypes were confirmed to be enriched among the differentially expressed genes between KD and normal samples from GEO datasets. Collectively, our findings indicate that cellular senescence may be one of the mechanisms of vascular endothelial damage in KD. PA may be a biomarker and potential therapeutic target for predicting the occurrence of CALs in KD patients. All things considered, our findings confirm that plasma metabolomics was able to identify promising biomarkers and potential pathogenesis mechanisms in KD. To conclude, Palmitic acid could be a novel target in future studies of CALs in patients with KD.
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spelling pubmed-89839372022-04-07 Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease Zhu, Qiongjun Dong, Qianqian Wang, Xuliang Xia, Tianhe Fu, Yu Wang, Qiaoyu Wu, Rongzhou Wu, Tingting Front Pharmacol Pharmacology Coronary artery lesions (CALs) are severe complications of Kawasaki disease (KD), resulting in stenosis and thrombogenesis. Metabolomic profiling of patients’ plasma could assist in elucidating the pathogenesis of CALs and identifying diagnostic biomarkers, which are imperative for clinical treatment. The metabolic profiles between KD patients with CALs and without CALs (non-coronary artery lesion, or NCAL, group) indicated the most significantly differentially expressed metabolite, palmitic acid (PA), showed the most massive fold change at 9.879. Furthermore, PA was proven to aggravate endothelial cellular senescence by increasing the generation of reactive oxygen species (ROS) in KD, and those two phenotypes were confirmed to be enriched among the differentially expressed genes between KD and normal samples from GEO datasets. Collectively, our findings indicate that cellular senescence may be one of the mechanisms of vascular endothelial damage in KD. PA may be a biomarker and potential therapeutic target for predicting the occurrence of CALs in KD patients. All things considered, our findings confirm that plasma metabolomics was able to identify promising biomarkers and potential pathogenesis mechanisms in KD. To conclude, Palmitic acid could be a novel target in future studies of CALs in patients with KD. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8983937/ /pubmed/35401162 http://dx.doi.org/10.3389/fphar.2022.809157 Text en Copyright © 2022 Zhu, Dong, Wang, Xia, Fu, Wang, Wu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhu, Qiongjun
Dong, Qianqian
Wang, Xuliang
Xia, Tianhe
Fu, Yu
Wang, Qiaoyu
Wu, Rongzhou
Wu, Tingting
Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title_full Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title_fullStr Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title_full_unstemmed Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title_short Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease
title_sort palmitic acid, a critical metabolite, aggravates cellular senescence through reactive oxygen species generation in kawasaki disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983937/
https://www.ncbi.nlm.nih.gov/pubmed/35401162
http://dx.doi.org/10.3389/fphar.2022.809157
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