PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease

Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes adipocyte differentiation, stimulates adipogenesis, and has the properties of anti-atherosclerosis, anti-inflammation, and anti-oxidat...

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Autores principales: Song, Yongyan, Li, Shujin, He, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984027/
https://www.ncbi.nlm.nih.gov/pubmed/35402540
http://dx.doi.org/10.3389/fcvm.2022.808929
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author Song, Yongyan
Li, Shujin
He, Chuan
author_facet Song, Yongyan
Li, Shujin
He, Chuan
author_sort Song, Yongyan
collection PubMed
description Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes adipocyte differentiation, stimulates adipogenesis, and has the properties of anti-atherosclerosis, anti-inflammation, and anti-oxidation. The Human PPARγ gene (PPARG) contains thousands of polymorphic loci, among them two polymorphisms (rs10865710 and rs7649970) in the promoter region and two polymorphisms (rs1801282 and rs3856806) in the exonic region were widely reported to be significantly associated with coronary artery disease (CAD). Mechanistically, PPARG polymorphisms lead to abnormal expression of PPARG gene and/or dysfunction of PPARγ protein, causing metabolic disorders such as hypercholesterolemia and hypertriglyceridemia, and thereby increasing susceptibility to CAD.
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spelling pubmed-89840272022-04-07 PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease Song, Yongyan Li, Shujin He, Chuan Front Cardiovasc Med Cardiovascular Medicine Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes adipocyte differentiation, stimulates adipogenesis, and has the properties of anti-atherosclerosis, anti-inflammation, and anti-oxidation. The Human PPARγ gene (PPARG) contains thousands of polymorphic loci, among them two polymorphisms (rs10865710 and rs7649970) in the promoter region and two polymorphisms (rs1801282 and rs3856806) in the exonic region were widely reported to be significantly associated with coronary artery disease (CAD). Mechanistically, PPARG polymorphisms lead to abnormal expression of PPARG gene and/or dysfunction of PPARγ protein, causing metabolic disorders such as hypercholesterolemia and hypertriglyceridemia, and thereby increasing susceptibility to CAD. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8984027/ /pubmed/35402540 http://dx.doi.org/10.3389/fcvm.2022.808929 Text en Copyright © 2022 Song, Li and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Song, Yongyan
Li, Shujin
He, Chuan
PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title_full PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title_fullStr PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title_full_unstemmed PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title_short PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
title_sort pparγ gene polymorphisms, metabolic disorders, and coronary artery disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984027/
https://www.ncbi.nlm.nih.gov/pubmed/35402540
http://dx.doi.org/10.3389/fcvm.2022.808929
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