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DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

DOT1L is essential for embryonic hematopoiesis but the precise mechanisms of its action remain unclear. The only recognized function of DOT1L is histone H3 lysine 79 (H3K79) methylation, which has been implicated in both transcriptional activation and repression. We observed that deletion of the mou...

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Detalles Bibliográficos
Autores principales:	Borosha, Shaon, Ratri, Anamika, Ghosh, Subhra, Malcom, Carrie A., Chakravarthi, V. Praveen, Vivian, Jay L., Fields, Timothy A., Rumi, M. A. Karim, Fields, Patrick E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984088/ https://www.ncbi.nlm.nih.gov/pubmed/35401699 http://dx.doi.org/10.3389/fgene.2022.828086

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