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Recent Advances of Pyridinone in Medicinal Chemistry
Pyridinones have been adopted as an important block in medicinal chemistry that could serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via established condensation reactions, the physicochemical properties of such a scaffold could be manipulated by adjustment o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984125/ https://www.ncbi.nlm.nih.gov/pubmed/35402370 http://dx.doi.org/10.3389/fchem.2022.869860 |
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author | Lin, Shibo Liu, Chun Zhao, Xiaotian Han, Xiao Li, Xuanhao Ye, Yongqin Li, Zheyu |
author_facet | Lin, Shibo Liu, Chun Zhao, Xiaotian Han, Xiao Li, Xuanhao Ye, Yongqin Li, Zheyu |
author_sort | Lin, Shibo |
collection | PubMed |
description | Pyridinones have been adopted as an important block in medicinal chemistry that could serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via established condensation reactions, the physicochemical properties of such a scaffold could be manipulated by adjustment of polarity, lipophilicity, and hydrogen bonding, and eventually lead to its wide application in fragment-based drug design, biomolecular mimetics, and kinase hinge-binding motifs. In addition, most pyridinone derivatives exhibit various biological activities ranging from antitumor, antimicrobial, anti-inflammatory, and anticoagulant to cardiotonic effects. This review focuses on recent contributions of pyridinone cores to medicinal chemistry, and addresses the structural features and structure–activity relationships (SARs) of each drug-like molecule. These advancements contribute to an in-depth understanding of the potential of this biologically enriched scaffold and expedite the development of its new applications in drug discovery. |
format | Online Article Text |
id | pubmed-8984125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89841252022-04-07 Recent Advances of Pyridinone in Medicinal Chemistry Lin, Shibo Liu, Chun Zhao, Xiaotian Han, Xiao Li, Xuanhao Ye, Yongqin Li, Zheyu Front Chem Chemistry Pyridinones have been adopted as an important block in medicinal chemistry that could serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via established condensation reactions, the physicochemical properties of such a scaffold could be manipulated by adjustment of polarity, lipophilicity, and hydrogen bonding, and eventually lead to its wide application in fragment-based drug design, biomolecular mimetics, and kinase hinge-binding motifs. In addition, most pyridinone derivatives exhibit various biological activities ranging from antitumor, antimicrobial, anti-inflammatory, and anticoagulant to cardiotonic effects. This review focuses on recent contributions of pyridinone cores to medicinal chemistry, and addresses the structural features and structure–activity relationships (SARs) of each drug-like molecule. These advancements contribute to an in-depth understanding of the potential of this biologically enriched scaffold and expedite the development of its new applications in drug discovery. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8984125/ /pubmed/35402370 http://dx.doi.org/10.3389/fchem.2022.869860 Text en Copyright © 2022 Lin, Liu, Zhao, Han, Li, Ye and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Lin, Shibo Liu, Chun Zhao, Xiaotian Han, Xiao Li, Xuanhao Ye, Yongqin Li, Zheyu Recent Advances of Pyridinone in Medicinal Chemistry |
title | Recent Advances of Pyridinone in Medicinal Chemistry |
title_full | Recent Advances of Pyridinone in Medicinal Chemistry |
title_fullStr | Recent Advances of Pyridinone in Medicinal Chemistry |
title_full_unstemmed | Recent Advances of Pyridinone in Medicinal Chemistry |
title_short | Recent Advances of Pyridinone in Medicinal Chemistry |
title_sort | recent advances of pyridinone in medicinal chemistry |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984125/ https://www.ncbi.nlm.nih.gov/pubmed/35402370 http://dx.doi.org/10.3389/fchem.2022.869860 |
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