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Gastric Cancer in Older Patients: A Retrospective Study and Literature Review
BACKGROUND: With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC. METHODS: A total of 2,983 patients diagnosed with ga...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Geriatrics Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984166/ https://www.ncbi.nlm.nih.gov/pubmed/35298880 http://dx.doi.org/10.4235/agmr.21.0144 |
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author | Choi, Yonghoon Kim, Nayoung Kim, Ki Wook Jo, Hyeong Ho Park, Jaehyung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho |
author_facet | Choi, Yonghoon Kim, Nayoung Kim, Ki Wook Jo, Hyeong Ho Park, Jaehyung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho |
author_sort | Choi, Yonghoon |
collection | PubMed |
description | BACKGROUND: With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC. METHODS: A total of 2,983 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment at Seoul National University Bundang Hospital between 2003 and 2017 were classified into three groups: I (<65 years, n=1,680), II (60–74 years, n=919), and III (≥75 years, n=384). We compared the baseline clinical characteristics, pathological characteristics of the tumor, overall and GC-specific survival rates, and associated risk factors between the groups. RESULTS: Cancer of the distal third of the stomach (p<0.001), with intestinal-type histology (p<0.001), and with p53 overexpression (p=0.004) were more common in groups II and III than in group I, and the proportion of intestinal-type GC increased with age. The cancer type, lymph node metastasis, and cancer stage did not differ significantly. In terms of overall survival, survival decreased with increasing age (p<0.001), but this difference decreased significantly for GC-specific survival. Cox multivariate analyses revealed age, histologic type (diffuse or mixed type), and advanced cancer stage (p=0.002, 0.001, and <0.001, respectively) as risk factors for GC-related mortality. CONCLUSION: Age itself was found to be one of the most important prognostic factors for overall and disease-specific survival in elderly GC patients, along with cancer stage. |
format | Online Article Text |
id | pubmed-8984166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Geriatrics Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-89841662022-04-13 Gastric Cancer in Older Patients: A Retrospective Study and Literature Review Choi, Yonghoon Kim, Nayoung Kim, Ki Wook Jo, Hyeong Ho Park, Jaehyung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Ann Geriatr Med Res Original Article BACKGROUND: With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC. METHODS: A total of 2,983 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment at Seoul National University Bundang Hospital between 2003 and 2017 were classified into three groups: I (<65 years, n=1,680), II (60–74 years, n=919), and III (≥75 years, n=384). We compared the baseline clinical characteristics, pathological characteristics of the tumor, overall and GC-specific survival rates, and associated risk factors between the groups. RESULTS: Cancer of the distal third of the stomach (p<0.001), with intestinal-type histology (p<0.001), and with p53 overexpression (p=0.004) were more common in groups II and III than in group I, and the proportion of intestinal-type GC increased with age. The cancer type, lymph node metastasis, and cancer stage did not differ significantly. In terms of overall survival, survival decreased with increasing age (p<0.001), but this difference decreased significantly for GC-specific survival. Cox multivariate analyses revealed age, histologic type (diffuse or mixed type), and advanced cancer stage (p=0.002, 0.001, and <0.001, respectively) as risk factors for GC-related mortality. CONCLUSION: Age itself was found to be one of the most important prognostic factors for overall and disease-specific survival in elderly GC patients, along with cancer stage. Korean Geriatrics Society 2022-03 2022-03-18 /pmc/articles/PMC8984166/ /pubmed/35298880 http://dx.doi.org/10.4235/agmr.21.0144 Text en Copyright © 2022 Korean Geriatrics Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Yonghoon Kim, Nayoung Kim, Ki Wook Jo, Hyeong Ho Park, Jaehyung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title | Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title_full | Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title_fullStr | Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title_full_unstemmed | Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title_short | Gastric Cancer in Older Patients: A Retrospective Study and Literature Review |
title_sort | gastric cancer in older patients: a retrospective study and literature review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984166/ https://www.ncbi.nlm.nih.gov/pubmed/35298880 http://dx.doi.org/10.4235/agmr.21.0144 |
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