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A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults
INTRODUCTION: The early detection of cognitive impairment is one of the most important challenges in Alzheimer's disease (AD) research. The use of brief, short‐term repeated test sessions via mobile app has demonstrated similar or better reliability and validity compared to standard in‐clinic a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984238/ https://www.ncbi.nlm.nih.gov/pubmed/35415201 http://dx.doi.org/10.1002/dad2.12283 |
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author | Thompson, Louisa I. Harrington, Karra D. Roque, Nelson Strenger, Jennifer Correia, Stephen Jones, Richard N. Salloway, Stephen Sliwinski, Martin J. |
author_facet | Thompson, Louisa I. Harrington, Karra D. Roque, Nelson Strenger, Jennifer Correia, Stephen Jones, Richard N. Salloway, Stephen Sliwinski, Martin J. |
author_sort | Thompson, Louisa I. |
collection | PubMed |
description | INTRODUCTION: The early detection of cognitive impairment is one of the most important challenges in Alzheimer's disease (AD) research. The use of brief, short‐term repeated test sessions via mobile app has demonstrated similar or better reliability and validity compared to standard in‐clinic assessments in adult samples. The present study examined adherence, acceptability, and reliability for a remote, app‐based cognitive screening protocol in healthy older adults. METHODS: Cognitively unimpaired older adults (N = 52, ages 60–80) completed three brief cognitive testing sessions per day within morning, afternoon, and evening time windows, for 8 consecutive days using a mobile app‐based cognitive testing platform. Cognitive tasks assessed visual working memory, processing speed, and episodic memory. RESULTS: Participants completed an average of 93% (M = 22.3 sessions, standard deviation = 10.2) of the 24 assigned sessions within 8 to 9 days. Average daily adherence ranged from 95% of sessions completed on day 2 to 88% of sessions completed on day 8. There was a statistically significant effect of session time on adherence between the morning and afternoon sessions only F (1, 51) = 9.15, P = .004, η (p ) (2 )= 0.152, with fewer afternoon sessions completed on average. The within‐person reliabilities of average scores, aggregated across all 24 sessions, were exceptionally high, ranging from 0.89 to 0.97. Performance on the episodic memory task was positively and significantly associated with total score and word list recall score on the Telephone Interview for Cognitive Status. In an exit survey, 65% of participants reported that they “definitely” would complete the sessions again. DISCUSSION: These findings suggests that remote, mobile app–based cognitive testing in short bursts is both highly feasible and reliable in a motivated sample of cognitively normal older adults. Limitations include the limited diversity and generalizability of the sample; this was a largely White, highly educated, and motivated sample self‐selected for AD research. |
format | Online Article Text |
id | pubmed-8984238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89842382022-04-11 A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults Thompson, Louisa I. Harrington, Karra D. Roque, Nelson Strenger, Jennifer Correia, Stephen Jones, Richard N. Salloway, Stephen Sliwinski, Martin J. Alzheimers Dement (Amst) Short Reports INTRODUCTION: The early detection of cognitive impairment is one of the most important challenges in Alzheimer's disease (AD) research. The use of brief, short‐term repeated test sessions via mobile app has demonstrated similar or better reliability and validity compared to standard in‐clinic assessments in adult samples. The present study examined adherence, acceptability, and reliability for a remote, app‐based cognitive screening protocol in healthy older adults. METHODS: Cognitively unimpaired older adults (N = 52, ages 60–80) completed three brief cognitive testing sessions per day within morning, afternoon, and evening time windows, for 8 consecutive days using a mobile app‐based cognitive testing platform. Cognitive tasks assessed visual working memory, processing speed, and episodic memory. RESULTS: Participants completed an average of 93% (M = 22.3 sessions, standard deviation = 10.2) of the 24 assigned sessions within 8 to 9 days. Average daily adherence ranged from 95% of sessions completed on day 2 to 88% of sessions completed on day 8. There was a statistically significant effect of session time on adherence between the morning and afternoon sessions only F (1, 51) = 9.15, P = .004, η (p ) (2 )= 0.152, with fewer afternoon sessions completed on average. The within‐person reliabilities of average scores, aggregated across all 24 sessions, were exceptionally high, ranging from 0.89 to 0.97. Performance on the episodic memory task was positively and significantly associated with total score and word list recall score on the Telephone Interview for Cognitive Status. In an exit survey, 65% of participants reported that they “definitely” would complete the sessions again. DISCUSSION: These findings suggests that remote, mobile app–based cognitive testing in short bursts is both highly feasible and reliable in a motivated sample of cognitively normal older adults. Limitations include the limited diversity and generalizability of the sample; this was a largely White, highly educated, and motivated sample self‐selected for AD research. John Wiley and Sons Inc. 2022-04-05 /pmc/articles/PMC8984238/ /pubmed/35415201 http://dx.doi.org/10.1002/dad2.12283 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Short Reports Thompson, Louisa I. Harrington, Karra D. Roque, Nelson Strenger, Jennifer Correia, Stephen Jones, Richard N. Salloway, Stephen Sliwinski, Martin J. A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title | A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title_full | A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title_fullStr | A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title_full_unstemmed | A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title_short | A highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
title_sort | highly feasible, reliable, and fully remote protocol for mobile app‐based cognitive assessment in cognitively healthy older adults |
topic | Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984238/ https://www.ncbi.nlm.nih.gov/pubmed/35415201 http://dx.doi.org/10.1002/dad2.12283 |
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