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Free fatty acids, glucose, and insulin in type 2 diabetes mellitus
Xu et al used the HOMA2 model to estimate the β-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels. This method is based on the assumption that the glucose-insulin axis is central for the metabolic activi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984573/ https://www.ncbi.nlm.nih.gov/pubmed/35432753 http://dx.doi.org/10.4239/wjd.v13.i3.275 |
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author | Weijers, Rob NM |
author_facet | Weijers, Rob NM |
author_sort | Weijers, Rob NM |
collection | PubMed |
description | Xu et al used the HOMA2 model to estimate the β-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels. This method is based on the assumption that the glucose-insulin axis is central for the metabolic activities, which led to type 2 diabetes. However, significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids (FFAs) into the blood circulation, which leads to a marked reduction in membrane flexibility. These data favor a FFA-glucose-insulin axis. The authors are invited to extend their study with the introduction of the saturation index (number of carbon-carbon double bonds per 100 fatty-acyl chains), as observed in erythrocytes. |
format | Online Article Text |
id | pubmed-8984573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-89845732022-04-15 Free fatty acids, glucose, and insulin in type 2 diabetes mellitus Weijers, Rob NM World J Diabetes Letter to the Editor Xu et al used the HOMA2 model to estimate the β-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels. This method is based on the assumption that the glucose-insulin axis is central for the metabolic activities, which led to type 2 diabetes. However, significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids (FFAs) into the blood circulation, which leads to a marked reduction in membrane flexibility. These data favor a FFA-glucose-insulin axis. The authors are invited to extend their study with the introduction of the saturation index (number of carbon-carbon double bonds per 100 fatty-acyl chains), as observed in erythrocytes. Baishideng Publishing Group Inc 2022-03-15 2022-03-15 /pmc/articles/PMC8984573/ /pubmed/35432753 http://dx.doi.org/10.4239/wjd.v13.i3.275 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Letter to the Editor Weijers, Rob NM Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title | Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title_full | Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title_fullStr | Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title_full_unstemmed | Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title_short | Free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
title_sort | free fatty acids, glucose, and insulin in type 2 diabetes mellitus |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984573/ https://www.ncbi.nlm.nih.gov/pubmed/35432753 http://dx.doi.org/10.4239/wjd.v13.i3.275 |
work_keys_str_mv | AT weijersrobnm freefattyacidsglucoseandinsulinintype2diabetesmellitus |