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Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older

BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using...

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Autores principales: Bai, Xiao-Fang, Wang, Huan, Zhao, Qiao-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984574/
https://www.ncbi.nlm.nih.gov/pubmed/35432751
http://dx.doi.org/10.4239/wjd.v13.i3.251
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author Bai, Xiao-Fang
Wang, Huan
Zhao, Qiao-Ling
author_facet Bai, Xiao-Fang
Wang, Huan
Zhao, Qiao-Ling
author_sort Bai, Xiao-Fang
collection PubMed
description BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using data from the 1999-2018 National Health and Nutrition Examination Survey. METHODS: This study was based on data from 44560 adults aged ≥ 16 years, excluding those with diabetes. The relationship was estimated using a multivariate regression. We also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on HbA1c. RESULTS: Hb and HbA1c levels were negatively correlated in the unadjusted model (β = -0.01; 95%CI: -0.01, -0.01). The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex, and remained negative when the model was further regulated (more than 10%) to identify covariates with the HbA1c level influence estimates. In subgroup analyses based on age and sex stratification, the association remained negative when the covariates were controlled. A nonlinear relationship was observed between them when the Hb levels reached the tipping point (13.2 g/dL) (adjusted odds ratio, -0.04; 95%CI: -0.05, -0.03) and when the Hb levels exceeded 13.2 g/dL (adjusted odds ratio, -0.10; 95%CI: -0.10, -0.09). CONCLUSION: Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years.
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spelling pubmed-89845742022-04-15 Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older Bai, Xiao-Fang Wang, Huan Zhao, Qiao-Ling World J Diabetes Retrospective Study BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using data from the 1999-2018 National Health and Nutrition Examination Survey. METHODS: This study was based on data from 44560 adults aged ≥ 16 years, excluding those with diabetes. The relationship was estimated using a multivariate regression. We also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on HbA1c. RESULTS: Hb and HbA1c levels were negatively correlated in the unadjusted model (β = -0.01; 95%CI: -0.01, -0.01). The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex, and remained negative when the model was further regulated (more than 10%) to identify covariates with the HbA1c level influence estimates. In subgroup analyses based on age and sex stratification, the association remained negative when the covariates were controlled. A nonlinear relationship was observed between them when the Hb levels reached the tipping point (13.2 g/dL) (adjusted odds ratio, -0.04; 95%CI: -0.05, -0.03) and when the Hb levels exceeded 13.2 g/dL (adjusted odds ratio, -0.10; 95%CI: -0.10, -0.09). CONCLUSION: Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years. Baishideng Publishing Group Inc 2022-03-15 2022-03-15 /pmc/articles/PMC8984574/ /pubmed/35432751 http://dx.doi.org/10.4239/wjd.v13.i3.251 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Study
Bai, Xiao-Fang
Wang, Huan
Zhao, Qiao-Ling
Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title_full Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title_fullStr Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title_full_unstemmed Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title_short Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
title_sort hemoglobin within normal range is negatively related to hemoglobin a1c in a nondiabetic american population aged 16 years and older
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984574/
https://www.ncbi.nlm.nih.gov/pubmed/35432751
http://dx.doi.org/10.4239/wjd.v13.i3.251
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