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Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984574/ https://www.ncbi.nlm.nih.gov/pubmed/35432751 http://dx.doi.org/10.4239/wjd.v13.i3.251 |
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author | Bai, Xiao-Fang Wang, Huan Zhao, Qiao-Ling |
author_facet | Bai, Xiao-Fang Wang, Huan Zhao, Qiao-Ling |
author_sort | Bai, Xiao-Fang |
collection | PubMed |
description | BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using data from the 1999-2018 National Health and Nutrition Examination Survey. METHODS: This study was based on data from 44560 adults aged ≥ 16 years, excluding those with diabetes. The relationship was estimated using a multivariate regression. We also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on HbA1c. RESULTS: Hb and HbA1c levels were negatively correlated in the unadjusted model (β = -0.01; 95%CI: -0.01, -0.01). The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex, and remained negative when the model was further regulated (more than 10%) to identify covariates with the HbA1c level influence estimates. In subgroup analyses based on age and sex stratification, the association remained negative when the covariates were controlled. A nonlinear relationship was observed between them when the Hb levels reached the tipping point (13.2 g/dL) (adjusted odds ratio, -0.04; 95%CI: -0.05, -0.03) and when the Hb levels exceeded 13.2 g/dL (adjusted odds ratio, -0.10; 95%CI: -0.10, -0.09). CONCLUSION: Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years. |
format | Online Article Text |
id | pubmed-8984574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-89845742022-04-15 Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older Bai, Xiao-Fang Wang, Huan Zhao, Qiao-Ling World J Diabetes Retrospective Study BACKGROUND: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. AIM: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using data from the 1999-2018 National Health and Nutrition Examination Survey. METHODS: This study was based on data from 44560 adults aged ≥ 16 years, excluding those with diabetes. The relationship was estimated using a multivariate regression. We also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on HbA1c. RESULTS: Hb and HbA1c levels were negatively correlated in the unadjusted model (β = -0.01; 95%CI: -0.01, -0.01). The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex, and remained negative when the model was further regulated (more than 10%) to identify covariates with the HbA1c level influence estimates. In subgroup analyses based on age and sex stratification, the association remained negative when the covariates were controlled. A nonlinear relationship was observed between them when the Hb levels reached the tipping point (13.2 g/dL) (adjusted odds ratio, -0.04; 95%CI: -0.05, -0.03) and when the Hb levels exceeded 13.2 g/dL (adjusted odds ratio, -0.10; 95%CI: -0.10, -0.09). CONCLUSION: Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years. Baishideng Publishing Group Inc 2022-03-15 2022-03-15 /pmc/articles/PMC8984574/ /pubmed/35432751 http://dx.doi.org/10.4239/wjd.v13.i3.251 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Retrospective Study Bai, Xiao-Fang Wang, Huan Zhao, Qiao-Ling Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title | Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title_full | Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title_fullStr | Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title_full_unstemmed | Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title_short | Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older |
title_sort | hemoglobin within normal range is negatively related to hemoglobin a1c in a nondiabetic american population aged 16 years and older |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984574/ https://www.ncbi.nlm.nih.gov/pubmed/35432751 http://dx.doi.org/10.4239/wjd.v13.i3.251 |
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