Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were d...

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Detalles Bibliográficos
Autores principales: Trang, Do Thi, Hang, Dan Thi Thuy, Dung, Duong Thi, Cuc, Nguyen Thi, Yen, Pham Hai, Huong, Phan Thi Thanh, Huyen, Le Thi, Mai, Nguyen Thi, Nhiem, Nguyen Xuan, Tai, Bui Huu, Van Kiem, Phan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984684/
https://www.ncbi.nlm.nih.gov/pubmed/35424966
http://dx.doi.org/10.1039/d2ra01674e
Descripción
Sumario:Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo(2)(OAc)(4) induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC(50) values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively.

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