Cargando…
Rhabdastrenones A–D from the sponge Rhabdastrella globostellata
Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were d...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984684/ https://www.ncbi.nlm.nih.gov/pubmed/35424966 http://dx.doi.org/10.1039/d2ra01674e |
| _version_ | 1784682242788818944 |
|---|---|
| author | Trang, Do Thi Hang, Dan Thi Thuy Dung, Duong Thi Cuc, Nguyen Thi Yen, Pham Hai Huong, Phan Thi Thanh Huyen, Le Thi Mai, Nguyen Thi Nhiem, Nguyen Xuan Tai, Bui Huu Van Kiem, Phan |
| author_facet | Trang, Do Thi Hang, Dan Thi Thuy Dung, Duong Thi Cuc, Nguyen Thi Yen, Pham Hai Huong, Phan Thi Thanh Huyen, Le Thi Mai, Nguyen Thi Nhiem, Nguyen Xuan Tai, Bui Huu Van Kiem, Phan |
| author_sort | Trang, Do Thi |
| collection | PubMed |
| description | Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo(2)(OAc)(4) induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC(50) values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively. |
| format | Online Article Text |
| id | pubmed-8984684 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89846842022-04-13 Rhabdastrenones A–D from the sponge Rhabdastrella globostellata Trang, Do Thi Hang, Dan Thi Thuy Dung, Duong Thi Cuc, Nguyen Thi Yen, Pham Hai Huong, Phan Thi Thanh Huyen, Le Thi Mai, Nguyen Thi Nhiem, Nguyen Xuan Tai, Bui Huu Van Kiem, Phan RSC Adv Chemistry Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo(2)(OAc)(4) induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC(50) values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively. The Royal Society of Chemistry 2022-04-06 /pmc/articles/PMC8984684/ /pubmed/35424966 http://dx.doi.org/10.1039/d2ra01674e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Trang, Do Thi Hang, Dan Thi Thuy Dung, Duong Thi Cuc, Nguyen Thi Yen, Pham Hai Huong, Phan Thi Thanh Huyen, Le Thi Mai, Nguyen Thi Nhiem, Nguyen Xuan Tai, Bui Huu Van Kiem, Phan Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title | Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title_full | Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title_fullStr | Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title_full_unstemmed | Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title_short | Rhabdastrenones A–D from the sponge Rhabdastrella globostellata |
| title_sort | rhabdastrenones a–d from the sponge rhabdastrella globostellata |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984684/ https://www.ncbi.nlm.nih.gov/pubmed/35424966 http://dx.doi.org/10.1039/d2ra01674e |
| work_keys_str_mv | AT trangdothi rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT hangdanthithuy rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT dungduongthi rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT cucnguyenthi rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT yenphamhai rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT huongphanthithanh rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT huyenlethi rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT mainguyenthi rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT nhiemnguyenxuan rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT taibuihuu rhabdastrenonesadfromthespongerhabdastrellaglobostellata AT vankiemphan rhabdastrenonesadfromthespongerhabdastrellaglobostellata |