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Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review

PURPOSE: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. METHODS: PubMed, Scopus, CINAHL, and Embase were sea...

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Autores principales: Khosla, Lakshay, Gong, Susan, Weiss, Jeffrey P., Birder, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984698/
https://www.ncbi.nlm.nih.gov/pubmed/35368181
http://dx.doi.org/10.5213/inj.2142188.094
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author Khosla, Lakshay
Gong, Susan
Weiss, Jeffrey P.
Birder, Lori A.
author_facet Khosla, Lakshay
Gong, Susan
Weiss, Jeffrey P.
Birder, Lori A.
author_sort Khosla, Lakshay
collection PubMed
description PURPOSE: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. METHODS: PubMed, Scopus, CINAHL, and Embase were searched for peer-reviewed studies published between January 2000 and March 2021. Animal and human studies that reported on the impact of oxidative stress in age-related LUT disorders through structural or functional changes in the LUT and changes in biomarkers were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol was followed. RESULTS: Of 882 articles identified, 21 studies (13 animal; 8 human) met inclusion criteria. Across LUT disorders, common structural changes were increased bladder and prostate weights, ischemic damage, nerve damage and detrusor muscle hypertrophy; common functional changes included decreased bladder contraction, increased bladder sensation and excitability, decreased perfusion, and increased inflammation. The disorders were associated with increased levels of biomarkers of oxidative stress that provided evidence of either molecular damage, protective mechanisms against oxidative stress, neural changes, or inflammation. In all cases, the effect on biomarkers and enzymes was greater in aged groups compared to younger groups. CONCLUSIONS: Increased oxidative stress, often associated with mitochondrial dysfunction, plays a significant role in the pathogenesis of age-related LUT disorders and may explain their increasing prevalence. This systematic review identifies potential markers of disease progression and treatment opportunities; further research is warranted to evaluate these markers and the mechanisms by which these changes may lead to age-related LUT disorders.
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spelling pubmed-89846982022-04-12 Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review Khosla, Lakshay Gong, Susan Weiss, Jeffrey P. Birder, Lori A. Int Neurourol J Review Article PURPOSE: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. METHODS: PubMed, Scopus, CINAHL, and Embase were searched for peer-reviewed studies published between January 2000 and March 2021. Animal and human studies that reported on the impact of oxidative stress in age-related LUT disorders through structural or functional changes in the LUT and changes in biomarkers were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol was followed. RESULTS: Of 882 articles identified, 21 studies (13 animal; 8 human) met inclusion criteria. Across LUT disorders, common structural changes were increased bladder and prostate weights, ischemic damage, nerve damage and detrusor muscle hypertrophy; common functional changes included decreased bladder contraction, increased bladder sensation and excitability, decreased perfusion, and increased inflammation. The disorders were associated with increased levels of biomarkers of oxidative stress that provided evidence of either molecular damage, protective mechanisms against oxidative stress, neural changes, or inflammation. In all cases, the effect on biomarkers and enzymes was greater in aged groups compared to younger groups. CONCLUSIONS: Increased oxidative stress, often associated with mitochondrial dysfunction, plays a significant role in the pathogenesis of age-related LUT disorders and may explain their increasing prevalence. This systematic review identifies potential markers of disease progression and treatment opportunities; further research is warranted to evaluate these markers and the mechanisms by which these changes may lead to age-related LUT disorders. Korean Continence Society 2022-03 2022-03-31 /pmc/articles/PMC8984698/ /pubmed/35368181 http://dx.doi.org/10.5213/inj.2142188.094 Text en Copyright © 2022 Korean Continence Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khosla, Lakshay
Gong, Susan
Weiss, Jeffrey P.
Birder, Lori A.
Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title_full Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title_fullStr Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title_full_unstemmed Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title_short Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review
title_sort oxidative stress biomarkers in age-related lower urinary tract disorders: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984698/
https://www.ncbi.nlm.nih.gov/pubmed/35368181
http://dx.doi.org/10.5213/inj.2142188.094
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