Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review

Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about the impact of cART on disease outcomes in patients with HIV-associated nephropathy (H...

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Autores principales: Adnani, Harsha, Agrawal, Nirav, Khatri, Akshay, Vialet, Jaclyn, Zhang, Meng, Cervia, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984856/
https://www.ncbi.nlm.nih.gov/pubmed/35369795
http://dx.doi.org/10.1177/23259582221089194
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author Adnani, Harsha
Agrawal, Nirav
Khatri, Akshay
Vialet, Jaclyn
Zhang, Meng
Cervia, Joseph
author_facet Adnani, Harsha
Agrawal, Nirav
Khatri, Akshay
Vialet, Jaclyn
Zhang, Meng
Cervia, Joseph
author_sort Adnani, Harsha
collection PubMed
description Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about the impact of cART on disease outcomes in patients with HIV-associated nephropathy (HIVAN) and HIV-immune complex kidney disease (HIVICK). This systematic review evaluates the impact of cART on progression to end-stage kidney disease (ESKD) and other outcomes in HIV-infected individuals. We conducted a literature search utilizing PubMed, and Cochrane database and 11 articles met inclusion criteria for analysis of which nine HIVAN studies showed decreased progression to ESKD or death for subjects when treated with cART versus those untreated. However, two studies showed no survival advantage with cART. Three HIVICK studies showed improvement in delaying ESKD in subjects on cART compared to untreated subjects. cART appeared to reduce the risk to ESKD or death in patients with both HIVAN and HIVICK.
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spelling pubmed-89848562022-04-07 Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review Adnani, Harsha Agrawal, Nirav Khatri, Akshay Vialet, Jaclyn Zhang, Meng Cervia, Joseph J Int Assoc Provid AIDS Care Review Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about the impact of cART on disease outcomes in patients with HIV-associated nephropathy (HIVAN) and HIV-immune complex kidney disease (HIVICK). This systematic review evaluates the impact of cART on progression to end-stage kidney disease (ESKD) and other outcomes in HIV-infected individuals. We conducted a literature search utilizing PubMed, and Cochrane database and 11 articles met inclusion criteria for analysis of which nine HIVAN studies showed decreased progression to ESKD or death for subjects when treated with cART versus those untreated. However, two studies showed no survival advantage with cART. Three HIVICK studies showed improvement in delaying ESKD in subjects on cART compared to untreated subjects. cART appeared to reduce the risk to ESKD or death in patients with both HIVAN and HIVICK. SAGE Publications 2022-04-04 /pmc/articles/PMC8984856/ /pubmed/35369795 http://dx.doi.org/10.1177/23259582221089194 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Adnani, Harsha
Agrawal, Nirav
Khatri, Akshay
Vialet, Jaclyn
Zhang, Meng
Cervia, Joseph
Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title_full Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title_fullStr Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title_full_unstemmed Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title_short Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review
title_sort impact of antiretroviral therapy on kidney disease in hiv infected individuals – a qualitative systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984856/
https://www.ncbi.nlm.nih.gov/pubmed/35369795
http://dx.doi.org/10.1177/23259582221089194
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