Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, structure, and position of the hairpin loop control the spectroscopic properties of long loop G-quadruplexes, and highlight that intrinsic fluorescence ca...

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Detalles Bibliográficos
Autores principales: Feng, Hengxin, Kwok, Chun Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984947/
https://www.ncbi.nlm.nih.gov/pubmed/35441140
http://dx.doi.org/10.1039/d2cb00045h
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author Feng, Hengxin
Kwok, Chun Kit
author_facet Feng, Hengxin
Kwok, Chun Kit
author_sort Feng, Hengxin
collection PubMed
description We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, structure, and position of the hairpin loop control the spectroscopic properties of long loop G-quadruplexes, and highlight that intrinsic fluorescence can be used to monitor the formation of non-canonical G-quadruplexes.
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spelling pubmed-89849472022-04-18 Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures Feng, Hengxin Kwok, Chun Kit RSC Chem Biol Chemistry We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, structure, and position of the hairpin loop control the spectroscopic properties of long loop G-quadruplexes, and highlight that intrinsic fluorescence can be used to monitor the formation of non-canonical G-quadruplexes. RSC 2022-03-10 /pmc/articles/PMC8984947/ /pubmed/35441140 http://dx.doi.org/10.1039/d2cb00045h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Feng, Hengxin
Kwok, Chun Kit
Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title_full Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title_fullStr Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title_full_unstemmed Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title_short Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
title_sort spectroscopic analysis reveals the effect of hairpin loop formation on g-quadruplex structures
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984947/
https://www.ncbi.nlm.nih.gov/pubmed/35441140
http://dx.doi.org/10.1039/d2cb00045h
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AT kwokchunkit spectroscopicanalysisrevealstheeffectofhairpinloopformationongquadruplexstructures

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