dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region

Bifurcation of cellular fates, a critical process in development, requires histone 3 lysine 27 methylation (H3K27me3) marks propagated by the polycomb repressive complex 2 (PRC2). However, precise chromatin loci of functional H3K27me3 marks are not yet known. Here, we identify critical PRC2 function...

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Detalles Bibliográficos
Autores principales: Levy, Shiri, Somasundaram, Logeshwaran, Raj, Infencia Xavier, Ic-Mex, Diego, Phal, Ashish, Schmidt, Sven, Ng, Weng I., Mar, Daniel, Decarreau, Justin, Moss, Nicholas, Alghadeer, Ammar, Honkanen, Henrik, Sarthy, Jay, Vitanza, Nicholas, Hawkins, R. David, Mathieu, Julie, Wang, Yuliang, Baker, David, Bomsztyk, Karol, Ruohola-Baker, Hannele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984963/
https://www.ncbi.nlm.nih.gov/pubmed/35235780
http://dx.doi.org/10.1016/j.celrep.2022.110457

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