X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-d-glucose in solid state and solution

The structural studies on two bromo-substituted derivatives of 2-deoxy-d-glucose (2-DG), namely 2-deoxy-2-bromo-d-glucose (2-BG) and 2-deoxy-2-bromo-d-mannose (2-BM) are described. 2-DG itself is an inhibitor of hexokinase, the first enzyme in the glycolysis process, playing a vital role in both can...

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Detalles Bibliográficos
Autores principales: Ziemniak, Marcin, Pawlędzio, Sylwia, Zawadzka-Kaźmierczuk, Anna, Dominiak, Paulina M., Trzybiński, Damian, Koźmiński, Wiktor, Zieliński, Rafał, Fokt, Izabela, Priebe, Waldemar, Woźniak, Krzysztof, Pająk, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985090/
https://www.ncbi.nlm.nih.gov/pubmed/35424802
http://dx.doi.org/10.1039/d1ra08312k

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