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Identification, synthesis and characterization of avanafil process impurities and determination by UPLC

Avanafil is a phosphodiesterase type 5 inhibitor which is used to treat erectile dysfunction in men. The process-related impurities of avanafil were investigated, and four kinds of impurities in several laboratory batches with a content of 0.29–1.63% were detected by the newly developed gradient ult...

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Detalles Bibliográficos
Autores principales:	Zhao, Mengmeng, Wu, Xiaoxia, Yu, Zengda, Sun, Yunkai, Liu, Zhao, Yuan, Jinqiao, Liu, Hu, Jin, Yiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985152/ https://www.ncbi.nlm.nih.gov/pubmed/35424898 http://dx.doi.org/10.1039/d2ra01224c

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