Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

Sirtuin2 (Sirt2) with its NAD(+)-dependent deacetylase and defatty-acylase activities plays a central role in the regulation of specific cellular functions. Dysregulation of Sirt2 activity has been associated with the pathogenesis of many diseases, thus making Sirt2 a promising target for pharmaceut...

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Detalles Bibliográficos
Autores principales: Vogelmann, A., Schiedel, M., Wössner, N., Merz, A., Herp, D., Hammelmann, S., Colcerasa, A., Komaniecki, G., Hong, JY., Sum, M., Metzger, E., Neuwirt, E., Zhang, L., Einsle, O., Groß, O., Schüle, R., Lin, H., Sippl, W., Jung, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985159/
https://www.ncbi.nlm.nih.gov/pubmed/35441145
http://dx.doi.org/10.1039/d1cb00244a

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