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Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents

The blends of poly(l-lactide acid-p-dioxanone-glycolide) (PLPG) with poly(d-lactide) (PDLA) (PLPG/PDLA) were prepared by a solution-casting method. The effects of PDLA on the properties of the PLPG were studied. DSC and WAXD results confirmed that PLA stereocomplex (sc-PLA) crystals were formed by b...

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Autores principales: Fan, Tiantang, Qin, Jingwen, Dong, Fen, Meng, Xiao, Li, Yanqi, Wang, Ying, Liu, Qing, Wang, Guannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985167/
https://www.ncbi.nlm.nih.gov/pubmed/35424991
http://dx.doi.org/10.1039/d2ra00525e
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author Fan, Tiantang
Qin, Jingwen
Dong, Fen
Meng, Xiao
Li, Yanqi
Wang, Ying
Liu, Qing
Wang, Guannan
author_facet Fan, Tiantang
Qin, Jingwen
Dong, Fen
Meng, Xiao
Li, Yanqi
Wang, Ying
Liu, Qing
Wang, Guannan
author_sort Fan, Tiantang
collection PubMed
description The blends of poly(l-lactide acid-p-dioxanone-glycolide) (PLPG) with poly(d-lactide) (PDLA) (PLPG/PDLA) were prepared by a solution-casting method. The effects of PDLA on the properties of the PLPG were studied. DSC and WAXD results confirmed that PLA stereocomplex (sc-PLA) crystals were formed by blending PLLA segments in PLPG with PDLA, and the melting endotherm for both PLLA and sc-PLA relied on PDLA content. The non-isothermal crystallization results indicated that the crystallization process was remarkably accelerated by the addition of PDLA. Meanwhile, the results of isothermal crystallization indicated that the half-time of crystallization decreased with the increase of PDLA content. Besides, the enzymatic degradation behavior of the samples showed that with the increase of PDLA content, the mass loss gradually decreased. Furthermore, TGA and DTG results indicated that the thermal degradation of the samples was a complex process. Moreover, the biocompatibility of the samples was tested by cell culture and using CCK-8 and live/dead staining. Results showed that the samples possessed lower cytotoxicity. Therefore, the PLPG/PDLA blends are promising candidate materials in biomedical applications.
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spelling pubmed-89851672022-04-13 Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents Fan, Tiantang Qin, Jingwen Dong, Fen Meng, Xiao Li, Yanqi Wang, Ying Liu, Qing Wang, Guannan RSC Adv Chemistry The blends of poly(l-lactide acid-p-dioxanone-glycolide) (PLPG) with poly(d-lactide) (PDLA) (PLPG/PDLA) were prepared by a solution-casting method. The effects of PDLA on the properties of the PLPG were studied. DSC and WAXD results confirmed that PLA stereocomplex (sc-PLA) crystals were formed by blending PLLA segments in PLPG with PDLA, and the melting endotherm for both PLLA and sc-PLA relied on PDLA content. The non-isothermal crystallization results indicated that the crystallization process was remarkably accelerated by the addition of PDLA. Meanwhile, the results of isothermal crystallization indicated that the half-time of crystallization decreased with the increase of PDLA content. Besides, the enzymatic degradation behavior of the samples showed that with the increase of PDLA content, the mass loss gradually decreased. Furthermore, TGA and DTG results indicated that the thermal degradation of the samples was a complex process. Moreover, the biocompatibility of the samples was tested by cell culture and using CCK-8 and live/dead staining. Results showed that the samples possessed lower cytotoxicity. Therefore, the PLPG/PDLA blends are promising candidate materials in biomedical applications. The Royal Society of Chemistry 2022-04-06 /pmc/articles/PMC8985167/ /pubmed/35424991 http://dx.doi.org/10.1039/d2ra00525e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Fan, Tiantang
Qin, Jingwen
Dong, Fen
Meng, Xiao
Li, Yanqi
Wang, Ying
Liu, Qing
Wang, Guannan
Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title_full Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title_fullStr Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title_full_unstemmed Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title_short Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
title_sort effects on the crystallization behavior and biocompatibility of poly(lla-ran-pdo-ran-ga) with poly(d-lactide) as nucleating agents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985167/
https://www.ncbi.nlm.nih.gov/pubmed/35424991
http://dx.doi.org/10.1039/d2ra00525e
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