The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis...

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Detalles Bibliográficos
Autores principales: Pham, Truc Lam, Zilke, Jennifer, Müller, Christine Charlotte, Thomas, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985196/
https://www.ncbi.nlm.nih.gov/pubmed/35441139
http://dx.doi.org/10.1039/d1cb00252j
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author Pham, Truc Lam
Zilke, Jennifer
Müller, Christine Charlotte
Thomas, Franziska
author_facet Pham, Truc Lam
Zilke, Jennifer
Müller, Christine Charlotte
Thomas, Franziska
author_sort Pham, Truc Lam
collection PubMed
description This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.
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spelling pubmed-89851962022-04-18 The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides Pham, Truc Lam Zilke, Jennifer Müller, Christine Charlotte Thomas, Franziska RSC Chem Biol Chemistry This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides. RSC 2022-02-18 /pmc/articles/PMC8985196/ /pubmed/35441139 http://dx.doi.org/10.1039/d1cb00252j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pham, Truc Lam
Zilke, Jennifer
Müller, Christine Charlotte
Thomas, Franziska
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title_full The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title_fullStr The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title_full_unstemmed The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title_short The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
title_sort csy-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985196/
https://www.ncbi.nlm.nih.gov/pubmed/35441139
http://dx.doi.org/10.1039/d1cb00252j
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