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Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial
PURPOSE: The early identification of maximum tolerated dose (MTD) in phase I trial leads to faster progression to a phase II trial or an expansion cohort to confirm efficacy. METHODS: We propose a novel adaptive design for identifying MTD early to accelerate dose-finding trials. The early identifica...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985324/ https://www.ncbi.nlm.nih.gov/pubmed/35382745 http://dx.doi.org/10.1186/s12874-022-01584-y |