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Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index
BACKGROUND: Data on whether physical activity (PA) levels are related to nonalcoholic fatty liver disease (NAFLD) when considering body mass index (BMI) are scarce. We assessed whether PA affects the development or resolution of NAFLD in conjunction with BMI changes. METHODS: Overall, 130,144 partic...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985384/ https://www.ncbi.nlm.nih.gov/pubmed/35382785 http://dx.doi.org/10.1186/s12889-022-13128-6 |
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author | Choi, Hyo-In Lee, Mi Yeon Kim, Hyunah Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Lee, Jong-Young Sung, Ki-Chul |
author_facet | Choi, Hyo-In Lee, Mi Yeon Kim, Hyunah Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Lee, Jong-Young Sung, Ki-Chul |
author_sort | Choi, Hyo-In |
collection | PubMed |
description | BACKGROUND: Data on whether physical activity (PA) levels are related to nonalcoholic fatty liver disease (NAFLD) when considering body mass index (BMI) are scarce. We assessed whether PA affects the development or resolution of NAFLD in conjunction with BMI changes. METHODS: Overall, 130,144 participants who underwent health screening during 2011–2016 were enrolled. According to the PA level in the Korean version of the validated International PA Questionnaire Short Form, participants were classified into the inactive, active, and health-enhancing PA (HEPA) groups. RESULTS: In participants with increased BMI, the hazard ratio (HR) and 95% confidence interval after multivariable Cox hazard model for incident NAFLD was 0.97 (0.94–1.01) in the active group and 0.94 (0.89–0.99) in the HEPA group, whereas that for NAFLD resolution was 1.03 (0.92–1.16) and 1.04 (0.88–1.23) (reference: inactive group). With increased BMI, high PA affected only new incident NAFLD. PA enhancement or maintenance of sufficient PA prevented new incident NAFLD. In participants with decreased BMI, the HRs were 0.98 (0.90–1.07) and 0.88 (0.78–0.99) for incident NAFLD and 1.07 (0.98–1.17) and 1.33 (1.18–1.49) for NAFLD resolution in the active and HEPA groups, respectively. With decreased BMI, high PA reduced incident NAFLD and increased NAFLD resolution. Maintenance of sufficient PA led to a considerable resolution of NAFLD. CONCLUSION: In this large longitudinal study, PA prevented incident NAFLD regardless of BMI changes. For NAFLD resolution, sufficient PA was essential along with BMI decrease. Maintaining sufficient PA or increasing the PA level is crucial for NAFLD prevention or resolution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-13128-6. |
format | Online Article Text |
id | pubmed-8985384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89853842022-04-07 Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index Choi, Hyo-In Lee, Mi Yeon Kim, Hyunah Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Lee, Jong-Young Sung, Ki-Chul BMC Public Health Research BACKGROUND: Data on whether physical activity (PA) levels are related to nonalcoholic fatty liver disease (NAFLD) when considering body mass index (BMI) are scarce. We assessed whether PA affects the development or resolution of NAFLD in conjunction with BMI changes. METHODS: Overall, 130,144 participants who underwent health screening during 2011–2016 were enrolled. According to the PA level in the Korean version of the validated International PA Questionnaire Short Form, participants were classified into the inactive, active, and health-enhancing PA (HEPA) groups. RESULTS: In participants with increased BMI, the hazard ratio (HR) and 95% confidence interval after multivariable Cox hazard model for incident NAFLD was 0.97 (0.94–1.01) in the active group and 0.94 (0.89–0.99) in the HEPA group, whereas that for NAFLD resolution was 1.03 (0.92–1.16) and 1.04 (0.88–1.23) (reference: inactive group). With increased BMI, high PA affected only new incident NAFLD. PA enhancement or maintenance of sufficient PA prevented new incident NAFLD. In participants with decreased BMI, the HRs were 0.98 (0.90–1.07) and 0.88 (0.78–0.99) for incident NAFLD and 1.07 (0.98–1.17) and 1.33 (1.18–1.49) for NAFLD resolution in the active and HEPA groups, respectively. With decreased BMI, high PA reduced incident NAFLD and increased NAFLD resolution. Maintenance of sufficient PA led to a considerable resolution of NAFLD. CONCLUSION: In this large longitudinal study, PA prevented incident NAFLD regardless of BMI changes. For NAFLD resolution, sufficient PA was essential along with BMI decrease. Maintaining sufficient PA or increasing the PA level is crucial for NAFLD prevention or resolution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-13128-6. BioMed Central 2022-04-05 /pmc/articles/PMC8985384/ /pubmed/35382785 http://dx.doi.org/10.1186/s12889-022-13128-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Choi, Hyo-In Lee, Mi Yeon Kim, Hyunah Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Lee, Jong-Young Sung, Ki-Chul Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title | Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title_full | Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title_fullStr | Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title_full_unstemmed | Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title_short | Effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
title_sort | effect of physical activity on the development and the resolution of nonalcoholic fatty liver in relation to body mass index |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985384/ https://www.ncbi.nlm.nih.gov/pubmed/35382785 http://dx.doi.org/10.1186/s12889-022-13128-6 |
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