Clinical characterization of COVID-19 breakthrough infections, Philippines

We clinically characterized PCR detected breakthrough infections among partially/fully vaccinated cases with majority given an inactivated vaccine, CoronaVac. From 1 March to 15 July 2021, we detected 182 SARS-CoV-2 infections among vaccinated cases with 129 classified as breakthrough infections. Ma...

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Autores principales: Velasco, John Mark, Vila, Vicente, Diones, Paula Corazon, Valderama, Maria Theresa, Mendez, Cecille, Turao-Agoncillo, Ma. Melissa Monica, Chinnawirotpisan, Piyawan, Manasatienkij, Wudtichai, Joonlasak, Khajohn, Klungthong, Chonticha, Jones, Anthony, Fernandez, Stefan, Navarro, Fatima Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985401/
https://www.ncbi.nlm.nih.gov/pubmed/35413587
http://dx.doi.org/10.1016/j.jcv.2022.105157
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author Velasco, John Mark
Vila, Vicente
Diones, Paula Corazon
Valderama, Maria Theresa
Mendez, Cecille
Turao-Agoncillo, Ma. Melissa Monica
Chinnawirotpisan, Piyawan
Manasatienkij, Wudtichai
Joonlasak, Khajohn
Klungthong, Chonticha
Jones, Anthony
Fernandez, Stefan
Navarro, Fatima Claire
author_facet Velasco, John Mark
Vila, Vicente
Diones, Paula Corazon
Valderama, Maria Theresa
Mendez, Cecille
Turao-Agoncillo, Ma. Melissa Monica
Chinnawirotpisan, Piyawan
Manasatienkij, Wudtichai
Joonlasak, Khajohn
Klungthong, Chonticha
Jones, Anthony
Fernandez, Stefan
Navarro, Fatima Claire
author_sort Velasco, John Mark
collection PubMed
description We clinically characterized PCR detected breakthrough infections among partially/fully vaccinated cases with majority given an inactivated vaccine, CoronaVac. From 1 March to 15 July 2021, we detected 182 SARS-CoV-2 infections among vaccinated cases with 129 classified as breakthrough infections. Majority were male, 30–39 y.o., and were asymptomatic or mildly symptomatic with few severe cases. Alpha, Beta and Delta VOCs were detected from sequenced breakthrough infections. Healthcare workers had significantly lower Ct values(higher viral loads) versus non-HCWs. Our results underscore the importance of regular PCR screening for HCWs due to the risk of SARS-CoV-2 transmission from asymptomatic breakthrough infections and provide evidence supporting administration of a booster dose especially to HCWs
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spelling pubmed-89854012022-04-06 Clinical characterization of COVID-19 breakthrough infections, Philippines Velasco, John Mark Vila, Vicente Diones, Paula Corazon Valderama, Maria Theresa Mendez, Cecille Turao-Agoncillo, Ma. Melissa Monica Chinnawirotpisan, Piyawan Manasatienkij, Wudtichai Joonlasak, Khajohn Klungthong, Chonticha Jones, Anthony Fernandez, Stefan Navarro, Fatima Claire J Clin Virol Article We clinically characterized PCR detected breakthrough infections among partially/fully vaccinated cases with majority given an inactivated vaccine, CoronaVac. From 1 March to 15 July 2021, we detected 182 SARS-CoV-2 infections among vaccinated cases with 129 classified as breakthrough infections. Majority were male, 30–39 y.o., and were asymptomatic or mildly symptomatic with few severe cases. Alpha, Beta and Delta VOCs were detected from sequenced breakthrough infections. Healthcare workers had significantly lower Ct values(higher viral loads) versus non-HCWs. Our results underscore the importance of regular PCR screening for HCWs due to the risk of SARS-CoV-2 transmission from asymptomatic breakthrough infections and provide evidence supporting administration of a booster dose especially to HCWs The Author(s). Published by Elsevier B.V. 2022-06 2022-04-06 /pmc/articles/PMC8985401/ /pubmed/35413587 http://dx.doi.org/10.1016/j.jcv.2022.105157 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Velasco, John Mark
Vila, Vicente
Diones, Paula Corazon
Valderama, Maria Theresa
Mendez, Cecille
Turao-Agoncillo, Ma. Melissa Monica
Chinnawirotpisan, Piyawan
Manasatienkij, Wudtichai
Joonlasak, Khajohn
Klungthong, Chonticha
Jones, Anthony
Fernandez, Stefan
Navarro, Fatima Claire
Clinical characterization of COVID-19 breakthrough infections, Philippines
title Clinical characterization of COVID-19 breakthrough infections, Philippines
title_full Clinical characterization of COVID-19 breakthrough infections, Philippines
title_fullStr Clinical characterization of COVID-19 breakthrough infections, Philippines
title_full_unstemmed Clinical characterization of COVID-19 breakthrough infections, Philippines
title_short Clinical characterization of COVID-19 breakthrough infections, Philippines
title_sort clinical characterization of covid-19 breakthrough infections, philippines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985401/
https://www.ncbi.nlm.nih.gov/pubmed/35413587
http://dx.doi.org/10.1016/j.jcv.2022.105157
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