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HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia

HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL rearrangements or NPM1 mutations to mediate HOXA topologically associated domain (TAD) formation and drive aberrant transcription. However, the mechanism through which HOTTIP accesses CCCTC-binding factor (CTCF) chromati...

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Detalles Bibliográficos
Autores principales:	Luo, Huacheng, Zhu, Ganqian, Eshelman, Melanie A., Fung, Tsz Kan, Lai, Qian, Wang, Fei, Zeisig, Bernd B., Lesperance, Julia, Ma, Xiaoyan, Chen, Shi, Cesari, Nicholas, Cogle, Christopher, Chen, Baoan, Xu, Bing, Yang, Feng-Chun, So, Chi Wai Eric, Qiu, Yi, Xu, Mingjiang, Huang, Suming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985430/ https://www.ncbi.nlm.nih.gov/pubmed/35180428 http://dx.doi.org/10.1016/j.molcel.2022.01.014

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