Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination

Multifocal motor neuropathy (MMN) is a peripheral nerve disorder characterized by progressive, predominantly distal, asymmetric limb weakness with minimal or no sensory impairment, and characterized by the presence of antibodies (30-80% cases), mostly IgM, to the gangliosides, mainly ganglioside mon...

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Autores principales: Suresh, Krithika, Mereddy, Preethi, Lanciano, Nicholas, Alam, Md Didar Ul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985558/
https://www.ncbi.nlm.nih.gov/pubmed/35399455
http://dx.doi.org/10.7759/cureus.22918
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author Suresh, Krithika
Mereddy, Preethi
Lanciano, Nicholas
Alam, Md Didar Ul
author_facet Suresh, Krithika
Mereddy, Preethi
Lanciano, Nicholas
Alam, Md Didar Ul
author_sort Suresh, Krithika
collection PubMed
description Multifocal motor neuropathy (MMN) is a peripheral nerve disorder characterized by progressive, predominantly distal, asymmetric limb weakness with minimal or no sensory impairment, and characterized by the presence of antibodies (30-80% cases), mostly IgM, to the gangliosides, mainly ganglioside monosialic acid (GM1). We describe a case of MMN in a patient who developed symptoms of paresthesia and extremity weakness a few days after receiving the influenza vaccine and was found to have high titers of anti-GM1 IgM antibody levels. He was initially treated with intravenous immune globulin (IVIG) which is one of the mainstays of treatment but relapsed and was then successfully treated with plasma exchange.
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spelling pubmed-89855582022-04-08 Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination Suresh, Krithika Mereddy, Preethi Lanciano, Nicholas Alam, Md Didar Ul Cureus Internal Medicine Multifocal motor neuropathy (MMN) is a peripheral nerve disorder characterized by progressive, predominantly distal, asymmetric limb weakness with minimal or no sensory impairment, and characterized by the presence of antibodies (30-80% cases), mostly IgM, to the gangliosides, mainly ganglioside monosialic acid (GM1). We describe a case of MMN in a patient who developed symptoms of paresthesia and extremity weakness a few days after receiving the influenza vaccine and was found to have high titers of anti-GM1 IgM antibody levels. He was initially treated with intravenous immune globulin (IVIG) which is one of the mainstays of treatment but relapsed and was then successfully treated with plasma exchange. Cureus 2022-03-07 /pmc/articles/PMC8985558/ /pubmed/35399455 http://dx.doi.org/10.7759/cureus.22918 Text en Copyright © 2022, Suresh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Suresh, Krithika
Mereddy, Preethi
Lanciano, Nicholas
Alam, Md Didar Ul
Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title_full Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title_fullStr Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title_full_unstemmed Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title_short Anti-ganglioside Complex IgM Antibodies in Multifocal Motor Neuropathy Post-influenza Vaccination
title_sort anti-ganglioside complex igm antibodies in multifocal motor neuropathy post-influenza vaccination
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985558/
https://www.ncbi.nlm.nih.gov/pubmed/35399455
http://dx.doi.org/10.7759/cureus.22918
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