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Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis
PURPOSE: The role of allium vegetables or garlic supplements on reducing cancer risk was inconsistent between laboratory study findings and related epidemiologic studies. METHODS: Studies assessing the effect of allium vegetables and garlic supplement consumption on cancer risk were included in our...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985597/ https://www.ncbi.nlm.nih.gov/pubmed/35402472 http://dx.doi.org/10.3389/fnut.2021.746944 |
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author | Zhang, Qifan Zhao, Qing Shen, Yan Zhao, Fuping Zhu, Yan |
author_facet | Zhang, Qifan Zhao, Qing Shen, Yan Zhao, Fuping Zhu, Yan |
author_sort | Zhang, Qifan |
collection | PubMed |
description | PURPOSE: The role of allium vegetables or garlic supplements on reducing cancer risk was inconsistent between laboratory study findings and related epidemiologic studies. METHODS: Studies assessing the effect of allium vegetables and garlic supplement consumption on cancer risk were included in our meta-analysis. We used fixed- or random-effects models to pool effect measures to evaluate the highest and lowest consumption. A dose-response regression analysis was used to assess the association between allium vegetables, garlic supplements, and cancer risk. RESULTS: In a pooled analysis of 22 studies with 25 reports on allium vegetables, a high consumption of allium vegetables showed no significant association with cancer risk (relative risk [RR] = 0.97, 95% confidence interval [CI] 0.92–1.03) in a fixed-effects model. Similarly, garlic supplements were not found to be significantly associated with an increased risk of cancer (RR = 0.97, 95% CI 0.84–1.12) in a random-effects model involving a pooled analysis of 10 studies with 11 reports. Consumption of allium vegetables did not significantly correspond with cancer risk (P for nonlinearity = 0.958, P for linearity = 0.907). CONCLUSION: In this meta-analysis, we found no evidence that higher consumption of allium vegetables or garlic supplements reduced the risk of cancer; however, this finding requires further validation. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42021246947. |
format | Online Article Text |
id | pubmed-8985597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89855972022-04-07 Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis Zhang, Qifan Zhao, Qing Shen, Yan Zhao, Fuping Zhu, Yan Front Nutr Nutrition PURPOSE: The role of allium vegetables or garlic supplements on reducing cancer risk was inconsistent between laboratory study findings and related epidemiologic studies. METHODS: Studies assessing the effect of allium vegetables and garlic supplement consumption on cancer risk were included in our meta-analysis. We used fixed- or random-effects models to pool effect measures to evaluate the highest and lowest consumption. A dose-response regression analysis was used to assess the association between allium vegetables, garlic supplements, and cancer risk. RESULTS: In a pooled analysis of 22 studies with 25 reports on allium vegetables, a high consumption of allium vegetables showed no significant association with cancer risk (relative risk [RR] = 0.97, 95% confidence interval [CI] 0.92–1.03) in a fixed-effects model. Similarly, garlic supplements were not found to be significantly associated with an increased risk of cancer (RR = 0.97, 95% CI 0.84–1.12) in a random-effects model involving a pooled analysis of 10 studies with 11 reports. Consumption of allium vegetables did not significantly correspond with cancer risk (P for nonlinearity = 0.958, P for linearity = 0.907). CONCLUSION: In this meta-analysis, we found no evidence that higher consumption of allium vegetables or garlic supplements reduced the risk of cancer; however, this finding requires further validation. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42021246947. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8985597/ /pubmed/35402472 http://dx.doi.org/10.3389/fnut.2021.746944 Text en Copyright © 2022 Zhang, Zhao, Shen, Zhao and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Zhang, Qifan Zhao, Qing Shen, Yan Zhao, Fuping Zhu, Yan Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title | Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title_full | Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title_fullStr | Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title_short | Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis |
title_sort | allium vegetables, garlic supplements, and risk of cancer: a systematic review and meta-analysis |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985597/ https://www.ncbi.nlm.nih.gov/pubmed/35402472 http://dx.doi.org/10.3389/fnut.2021.746944 |
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