Structural and functional insight into the regulation of kinesin-1 by microtubule associated protein MAP7

The microtubule (MT)-associated protein, MAP7 is a required cofactor for kinesin-1 driven transport of intracellular cargoes. Using cryo-electron microscopy and single-molecule imaging, we investigated how MAP7 binds MTs and facilitates kinesin-1 motility. The MT-binding domain (MTBD) of MAP7 bound...

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Detalles Bibliográficos
Autores principales: Ferro, Luke S, Fang, Qianglin, Eshun-Wilson, Lisa, Fernandes, Jonathan, Jack, Amanda, Farrell, Daniel P, Golcuk, Mert, Huijben, Teun, Costa, Katelyn, Gur, Mert, DiMaio, Frank, Nogales, Eva, Yildiz, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985661/
https://www.ncbi.nlm.nih.gov/pubmed/35050657
http://dx.doi.org/10.1126/science.abf6154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985661/
https://www.ncbi.nlm.nih.gov/pubmed/35050657
http://dx.doi.org/10.1126/science.abf6154

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