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Structural and functional insight into the regulation of kinesin-1 by microtubule associated protein MAP7

The microtubule (MT)-associated protein, MAP7 is a required cofactor for kinesin-1 driven transport of intracellular cargoes. Using cryo-electron microscopy and single-molecule imaging, we investigated how MAP7 binds MTs and facilitates kinesin-1 motility. The MT-binding domain (MTBD) of MAP7 bound...

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Detalles Bibliográficos
Autores principales:	Ferro, Luke S, Fang, Qianglin, Eshun-Wilson, Lisa, Fernandes, Jonathan, Jack, Amanda, Farrell, Daniel P, Golcuk, Mert, Huijben, Teun, Costa, Katelyn, Gur, Mert, DiMaio, Frank, Nogales, Eva, Yildiz, Ahmet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985661/ https://www.ncbi.nlm.nih.gov/pubmed/35050657 http://dx.doi.org/10.1126/science.abf6154

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