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Thyroid Function Assessment in Saudi Males with Metabolic Syndrome
BACKGROUND: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985841/ https://www.ncbi.nlm.nih.gov/pubmed/35399801 http://dx.doi.org/10.4103/jpbs.jpbs_745_21 |
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author | Aldhafiri, Fahad Khalid Abdelgawad, Fathy Elsayed Bakri, Gihan Mohamed Mohamed Saber, Tamer |
author_facet | Aldhafiri, Fahad Khalid Abdelgawad, Fathy Elsayed Bakri, Gihan Mohamed Mohamed Saber, Tamer |
author_sort | Aldhafiri, Fahad Khalid |
collection | PubMed |
description | BACKGROUND: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. MATERIALS AND METHODS: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). RESULTS: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. CONCLUSION: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD). |
format | Online Article Text |
id | pubmed-8985841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-89858412022-04-07 Thyroid Function Assessment in Saudi Males with Metabolic Syndrome Aldhafiri, Fahad Khalid Abdelgawad, Fathy Elsayed Bakri, Gihan Mohamed Mohamed Saber, Tamer J Pharm Bioallied Sci Research Article BACKGROUND: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. MATERIALS AND METHODS: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). RESULTS: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. CONCLUSION: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD). Wolters Kluwer - Medknow 2021 2022-03-04 /pmc/articles/PMC8985841/ /pubmed/35399801 http://dx.doi.org/10.4103/jpbs.jpbs_745_21 Text en Copyright: © 2022 Journal of Pharmacy And Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Aldhafiri, Fahad Khalid Abdelgawad, Fathy Elsayed Bakri, Gihan Mohamed Mohamed Saber, Tamer Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title | Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title_full | Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title_fullStr | Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title_full_unstemmed | Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title_short | Thyroid Function Assessment in Saudi Males with Metabolic Syndrome |
title_sort | thyroid function assessment in saudi males with metabolic syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985841/ https://www.ncbi.nlm.nih.gov/pubmed/35399801 http://dx.doi.org/10.4103/jpbs.jpbs_745_21 |
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