Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). We show that KHK expression is tightly controlled and limited to a small number of organs and is down-regulated in liver and intestinal cancer cells. Loss of fructose m...

Descripción completa

Detalles Bibliográficos
Autores principales: Tee, Sui Seng, Kim, Nathaniel, Cullen, Quinlan, Eskandari, Roozbeh, Mamakhanyan, Arsen, Srouji, Rami M., Chirayil, Rachel, Jeong, Sangmoo, Shakiba, Mojdeh, Kastenhuber, Edward R., Chen, Shuibing, Sigel, Carlie, Lowe, Scott W., Jarnagin, William R., Thompson, Craig B., Schietinger, Andrea, Keshari, Kayvan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985914/
https://www.ncbi.nlm.nih.gov/pubmed/35385296
http://dx.doi.org/10.1126/sciadv.abm7985

Ejemplares similares

Ejemplares similares