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A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells
HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but weak HNF4α agonists alverine and benfl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985954/ https://www.ncbi.nlm.nih.gov/pubmed/35385524 http://dx.doi.org/10.1371/journal.pone.0266066 |