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Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model

BACKGROUND: Under-five mortality (U5M) is one of the most important and sensitive indicators of the health status of the community. Despite there having been a substantial reduction in U5M since 1990, its rate is still high in Sub-Saharan African countries. Thus, this study aimed to assess time to u...

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Autores principales: Yalew, Melaku, Arefaynie, Mastewal, Bitew, Gedamnesh, Amsalu, Erkihun Tadesse, Kefale, Bereket, Muche, Amare, Fentaw, Zinabu, Genetu Chanie, Muluken, Melaku, Mequannent Sharew, Adane, Bezawit, Damtie, Yitayish, Adane, Metadel, Ayele, Wolde Melese, Andargie, Assefa, Dewau, Reta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985961/
https://www.ncbi.nlm.nih.gov/pubmed/35385556
http://dx.doi.org/10.1371/journal.pone.0266595
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author Yalew, Melaku
Arefaynie, Mastewal
Bitew, Gedamnesh
Amsalu, Erkihun Tadesse
Kefale, Bereket
Muche, Amare
Fentaw, Zinabu
Genetu Chanie, Muluken
Melaku, Mequannent Sharew
Adane, Bezawit
Damtie, Yitayish
Adane, Metadel
Ayele, Wolde Melese
Andargie, Assefa
Dewau, Reta
author_facet Yalew, Melaku
Arefaynie, Mastewal
Bitew, Gedamnesh
Amsalu, Erkihun Tadesse
Kefale, Bereket
Muche, Amare
Fentaw, Zinabu
Genetu Chanie, Muluken
Melaku, Mequannent Sharew
Adane, Bezawit
Damtie, Yitayish
Adane, Metadel
Ayele, Wolde Melese
Andargie, Assefa
Dewau, Reta
author_sort Yalew, Melaku
collection PubMed
description BACKGROUND: Under-five mortality (U5M) is one of the most important and sensitive indicators of the health status of the community. Despite there having been a substantial reduction in U5M since 1990, its rate is still high in Sub-Saharan African countries. Thus, this study aimed to assess time to under-five mortality and its predictors in rural Ethiopia. METHODS: This study utilized a secondary analysis of the 2016 Ethiopia Demographic and Health Survey (EDHS). A total of 9,807 weighted under-five children selected at different stages were included in the analysis. The Kaplan-Meier and Cox’s-gamma shared frailty models were used to estimate survival time and to identify predictors of under-five mortality, respectively. An adjusted Hazard Ratio (AHR) along with a 95% Confidence Interval (CI) was used to measure the effect size and direction of the association. RESULTS: The study indicated that 6.69% (95% CI: 6.13, 7.30) of children died before celebrating their fifth birthday in rural Ethiopia. Of all the deaths, the median time to death was 27 months. After controlling the effect of cluster and other confounding factors, female sex (AHR = 0.62, 95% CI: 0.52, 0.75), ever born greater than five children (AHR = 1.40, 95% CI: 1.07, 1.83), very large size at birth (AHR = 1.33, 95% CI: 1.03 1.71), very small size at birth (AHR = 1.41, 95% CI: 1.10, 1.82), twin pregnancy (AHR = 3.5, 95% CI: 2.47, 4.88), not ever breastfeeding (AHR = 11.29, 95% CI: 9.03, 14.12), unimproved latrine (AHR = 3.44, 95% CI: 1.91, 6.17), covered by health insurance (AHR = 0.29, 95% CI: 0.12, 0.70) were predictors of under-five mortality. CONCLUSIONS: Still under-five mortality was high in rural Ethiopia as compared to the global under-five mortality rate. In the final model, sex of a child, the total number of children ever born, children’s size at birth, type of pregnancy, breastfeeding, type of toilet, and being covered by health insurance were significant predictors of under-five mortality. Further emphasis should be given to twin and not breastfeeding children, as well as households’ better encouraging membership of community health insurance and utilization of improved latrines.
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spelling pubmed-89859612022-04-07 Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model Yalew, Melaku Arefaynie, Mastewal Bitew, Gedamnesh Amsalu, Erkihun Tadesse Kefale, Bereket Muche, Amare Fentaw, Zinabu Genetu Chanie, Muluken Melaku, Mequannent Sharew Adane, Bezawit Damtie, Yitayish Adane, Metadel Ayele, Wolde Melese Andargie, Assefa Dewau, Reta PLoS One Research Article BACKGROUND: Under-five mortality (U5M) is one of the most important and sensitive indicators of the health status of the community. Despite there having been a substantial reduction in U5M since 1990, its rate is still high in Sub-Saharan African countries. Thus, this study aimed to assess time to under-five mortality and its predictors in rural Ethiopia. METHODS: This study utilized a secondary analysis of the 2016 Ethiopia Demographic and Health Survey (EDHS). A total of 9,807 weighted under-five children selected at different stages were included in the analysis. The Kaplan-Meier and Cox’s-gamma shared frailty models were used to estimate survival time and to identify predictors of under-five mortality, respectively. An adjusted Hazard Ratio (AHR) along with a 95% Confidence Interval (CI) was used to measure the effect size and direction of the association. RESULTS: The study indicated that 6.69% (95% CI: 6.13, 7.30) of children died before celebrating their fifth birthday in rural Ethiopia. Of all the deaths, the median time to death was 27 months. After controlling the effect of cluster and other confounding factors, female sex (AHR = 0.62, 95% CI: 0.52, 0.75), ever born greater than five children (AHR = 1.40, 95% CI: 1.07, 1.83), very large size at birth (AHR = 1.33, 95% CI: 1.03 1.71), very small size at birth (AHR = 1.41, 95% CI: 1.10, 1.82), twin pregnancy (AHR = 3.5, 95% CI: 2.47, 4.88), not ever breastfeeding (AHR = 11.29, 95% CI: 9.03, 14.12), unimproved latrine (AHR = 3.44, 95% CI: 1.91, 6.17), covered by health insurance (AHR = 0.29, 95% CI: 0.12, 0.70) were predictors of under-five mortality. CONCLUSIONS: Still under-five mortality was high in rural Ethiopia as compared to the global under-five mortality rate. In the final model, sex of a child, the total number of children ever born, children’s size at birth, type of pregnancy, breastfeeding, type of toilet, and being covered by health insurance were significant predictors of under-five mortality. Further emphasis should be given to twin and not breastfeeding children, as well as households’ better encouraging membership of community health insurance and utilization of improved latrines. Public Library of Science 2022-04-06 /pmc/articles/PMC8985961/ /pubmed/35385556 http://dx.doi.org/10.1371/journal.pone.0266595 Text en © 2022 Yalew et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yalew, Melaku
Arefaynie, Mastewal
Bitew, Gedamnesh
Amsalu, Erkihun Tadesse
Kefale, Bereket
Muche, Amare
Fentaw, Zinabu
Genetu Chanie, Muluken
Melaku, Mequannent Sharew
Adane, Bezawit
Damtie, Yitayish
Adane, Metadel
Ayele, Wolde Melese
Andargie, Assefa
Dewau, Reta
Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title_full Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title_fullStr Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title_full_unstemmed Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title_short Time to under-five mortality and its predictors in rural Ethiopia: Cox-gamma shared frailty model
title_sort time to under-five mortality and its predictors in rural ethiopia: cox-gamma shared frailty model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985961/
https://www.ncbi.nlm.nih.gov/pubmed/35385556
http://dx.doi.org/10.1371/journal.pone.0266595
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