Comparison of L-Carnitine and L-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH

Disrupted L-Carnitine (L-Car) homeostasis has been implicated in the development of pulmonary hypertension (PH). L-Car has been administered orally and intravenously causing systemic side effects. To the authors’ knowledge, there are no reports using L-Car or L-Car HCl as an inhaled aerosol through...

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Detalles Bibliográficos
Autores principales: Acosta, Maria F., Muralidhran, Priya, Abrahamson, Michael D., Grijalva, Carissa L., Carver, Megan, Tang, Haiyang, Klinger, Christina, Fineman, Jeffrey R., Black, Stephen M., Mansour, Heidi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985976/
https://www.ncbi.nlm.nih.gov/pubmed/33556627
http://dx.doi.org/10.1016/j.pupt.2021.101998

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