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A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease
BACKGROUND: Impulse control disorders are detrimental neuropsychiatric symptoms of Parkinson’s disease. Increased impulsivity is a predisposing factor for impulse control disorders and should therefore be controlled. Recently, mindfulness meditation as a non-drug therapy has been reported to be usef...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985985/ https://www.ncbi.nlm.nih.gov/pubmed/35385563 http://dx.doi.org/10.1371/journal.pone.0266354 |
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author | Koh, Jinsoo Takahashi, Maiko Ohmae, Yasuhiko Taruya, Junko Sakata, Mayumi Yasui, Masaaki Terada, Masaki Ito, Hidefumi |
author_facet | Koh, Jinsoo Takahashi, Maiko Ohmae, Yasuhiko Taruya, Junko Sakata, Mayumi Yasui, Masaaki Terada, Masaki Ito, Hidefumi |
author_sort | Koh, Jinsoo |
collection | PubMed |
description | BACKGROUND: Impulse control disorders are detrimental neuropsychiatric symptoms of Parkinson’s disease. Increased impulsivity is a predisposing factor for impulse control disorders and should therefore be controlled. Recently, mindfulness meditation as a non-drug therapy has been reported to be useful in improving neuropsychiatric symptoms, such as impulsivity. METHODS: We performed a prospective single-arm, open-label pilot trial to investigate the effectiveness of mindfulness meditation to control impulsivity in patients with Parkinson’s disease (UMIN clinical trials registry: UMIN000037779). RESULTS: Twenty patients with Parkinson’s disease were enrolled in an 8-week mindfulness meditation program. As a primary outcome, we investigated whether the score of the Barratt Impulsiveness Scale (BIS-11) was significantly reduced after the intervention. As an exploratory examination, functional connectivity changes were also assessed by resting-state functional magnetic resonance imaging. After the intervention, the BIS-11 score was decreased from 59.5 [55.6, 63.3] (mean [95% confidence interval]) to 55.2 [50.3, 60.1] (ΔBIS-11: -4.2, [-7.5, -0.9]). Functional connectivity was increased in the default mode network (DMN) at a cluster including the precuneus, posterior cingulate gyrus, and left posterior lobe (false discovery rate-adjusted p [FDR-p] = 0.046) and in the right frontoparietal network (FPN) at the medial frontal lobe (FDR-p = 0.039). CONCLUSIONS: This open-label, single-arm pilot study provided preliminary data for mindfulness meditation to control the impulsivity of patients with PD. A brief mindfulness meditation program may be effective in controlling impulsivity in PD and may change the functional connectivity of the DMN and right FPN. |
format | Online Article Text |
id | pubmed-8985985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89859852022-04-07 A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease Koh, Jinsoo Takahashi, Maiko Ohmae, Yasuhiko Taruya, Junko Sakata, Mayumi Yasui, Masaaki Terada, Masaki Ito, Hidefumi PLoS One Research Article BACKGROUND: Impulse control disorders are detrimental neuropsychiatric symptoms of Parkinson’s disease. Increased impulsivity is a predisposing factor for impulse control disorders and should therefore be controlled. Recently, mindfulness meditation as a non-drug therapy has been reported to be useful in improving neuropsychiatric symptoms, such as impulsivity. METHODS: We performed a prospective single-arm, open-label pilot trial to investigate the effectiveness of mindfulness meditation to control impulsivity in patients with Parkinson’s disease (UMIN clinical trials registry: UMIN000037779). RESULTS: Twenty patients with Parkinson’s disease were enrolled in an 8-week mindfulness meditation program. As a primary outcome, we investigated whether the score of the Barratt Impulsiveness Scale (BIS-11) was significantly reduced after the intervention. As an exploratory examination, functional connectivity changes were also assessed by resting-state functional magnetic resonance imaging. After the intervention, the BIS-11 score was decreased from 59.5 [55.6, 63.3] (mean [95% confidence interval]) to 55.2 [50.3, 60.1] (ΔBIS-11: -4.2, [-7.5, -0.9]). Functional connectivity was increased in the default mode network (DMN) at a cluster including the precuneus, posterior cingulate gyrus, and left posterior lobe (false discovery rate-adjusted p [FDR-p] = 0.046) and in the right frontoparietal network (FPN) at the medial frontal lobe (FDR-p = 0.039). CONCLUSIONS: This open-label, single-arm pilot study provided preliminary data for mindfulness meditation to control the impulsivity of patients with PD. A brief mindfulness meditation program may be effective in controlling impulsivity in PD and may change the functional connectivity of the DMN and right FPN. Public Library of Science 2022-04-06 /pmc/articles/PMC8985985/ /pubmed/35385563 http://dx.doi.org/10.1371/journal.pone.0266354 Text en © 2022 Koh et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Koh, Jinsoo Takahashi, Maiko Ohmae, Yasuhiko Taruya, Junko Sakata, Mayumi Yasui, Masaaki Terada, Masaki Ito, Hidefumi A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title | A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title_full | A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title_fullStr | A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title_full_unstemmed | A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title_short | A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson’s disease |
title_sort | single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in parkinson’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985985/ https://www.ncbi.nlm.nih.gov/pubmed/35385563 http://dx.doi.org/10.1371/journal.pone.0266354 |
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