Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis

Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology. Endoplasmic reticulum (ER) stress can activate the NLRP3 inflammasome, but the potential implication of ER...

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Detalles Bibliográficos
Autores principales: Marek-Iannucci, Stefanie, Yildirim, Asli D., Hamid, Syed M., Ozdemir, Asli B., Gomez, Angela C., Kocatürk, Begüm, Porritt, Rebecca A., Fishbein, Michael C., Iwawaki, Takao, Noval Rivas, Magali, Erbay, Ebru, Arditi, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986066/
https://www.ncbi.nlm.nih.gov/pubmed/35167493
http://dx.doi.org/10.1172/jci.insight.157203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986066/
https://www.ncbi.nlm.nih.gov/pubmed/35167493
http://dx.doi.org/10.1172/jci.insight.157203

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