Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceride-derived fatty acids. Since fatty acid uptake is...

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Detalles Bibliográficos
Autores principales: Heckel, Emilie, Cagnone, Gael, Agnihotri, Tapan, Cakir, Bertan, Das, Ashim, Kim, Jin Sung, Kim, Nicholas, Lavoie, Geneviève, Situ, Anu, Pundir, Sheetal, Sun, Ye, Wünnemann, Florian, Pierce, Kerry A., Dennis, Courtney, Mitchell, Grant A., Chemtob, Sylvain, Rezende, Flavio A., Andelfinger, Gregor, Clish, Clary B., Roux, Philippe P., Sapieha, Przemyslaw, Smith, Lois E.H., Joyal, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986067/
https://www.ncbi.nlm.nih.gov/pubmed/35167498
http://dx.doi.org/10.1172/jci.insight.154174

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