Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS

Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factor...

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Detalles Bibliográficos
Autores principales: Mortberg, Meredith A., Zhao, Hien T., Reidenbach, Andrew G., Gentile, Juliana E., Kuhn, Eric, O’Moore, Jill, Dooley, Patrick M., Connors, Theresa R., Mazur, Curt, Allen, Shona W., Trombetta, Bianca A., McManus, Alison, Moore, Matthew R., Liu, Jiewu, Cabin, Deborah E., Kordasiewicz, Holly B., Mathews, Joel, Arnold, Steven E., Vallabh, Sonia M., Minikel, Eric Vallabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986079/
https://www.ncbi.nlm.nih.gov/pubmed/35133987
http://dx.doi.org/10.1172/jci.insight.156532

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