Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene programs driving persistent lung fibrosis in aging, we performed RNA-Seq on lung fibroblasts isolated from young and aged mic...

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Detalles Bibliográficos
Autores principales: Pham, Tho X., Lee, Jisu, Guan, Jiazhen, Caporarello, Nunzia, Meridew, Jeffrey A., Jones, Dakota L., Tan, Qi, Huang, Steven K., Tschumperlin, Daniel J., Ligresti, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986080/
https://www.ncbi.nlm.nih.gov/pubmed/35167499
http://dx.doi.org/10.1172/jci.insight.153672

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