Next-generation T cell–activating vaccination increases influenza virus mutation prevalence

To determine the potential for viral adaptation to T cell responses, we probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell–based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, ve...

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Detalles Bibliográficos
Autores principales: Bull, Maireid B., Gu, Haogao, Ma, Fionn N. L., Perera, Liyanage P., Poon, Leo L. M., Valkenburg, Sophie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986104/
https://www.ncbi.nlm.nih.gov/pubmed/35385318
http://dx.doi.org/10.1126/sciadv.abl5209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986104/
https://www.ncbi.nlm.nih.gov/pubmed/35385318
http://dx.doi.org/10.1126/sciadv.abl5209

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