FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction

The mitochondrial integrated stress response (mitoISR) has emerged as a major adaptive pathway to respiratory chain deficiency, but both the tissue specificity of its regulation, and how mitoISR adapts to different levels of mitochondrial dysfunction are largely unknown. Here, we report that diverse...

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Detalles Bibliográficos
Autores principales: Croon, Marijana, Szczepanowska, Karolina, Popovic, Milica, Lienkamp, Christina, Senft, Katharina, Brandscheid, Christoph Paul, Bock, Theresa, Gnatzy-Feik, Leoni, Ashurov, Artem, Acton, Richard James, Kaul, Harshita, Pujol, Claire, Rosenkranz, Stephan, Krüger, Marcus, Trifunovic, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986112/
https://www.ncbi.nlm.nih.gov/pubmed/35385313
http://dx.doi.org/10.1126/sciadv.abn7105

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