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Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies
Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986132/ https://www.ncbi.nlm.nih.gov/pubmed/35392109 http://dx.doi.org/10.1016/j.eng.2017.01.003 |
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author | Escobar Ivirico, Jorge L. Bhattacharjee, Maumita Kuyinu, Emmanuel Nair, Lakshmi S. Laurencin, Cato T. |
author_facet | Escobar Ivirico, Jorge L. Bhattacharjee, Maumita Kuyinu, Emmanuel Nair, Lakshmi S. Laurencin, Cato T. |
author_sort | Escobar Ivirico, Jorge L. |
collection | PubMed |
description | Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have been beneficial in treating the disease but none is as effective as total knee arthroplasty (TKA). However, while TKA is an end-stage solution of the disease, it is an invasive and expensive procedure. Therefore, innovative regenerative engineering strategies should be established as these could defer or annul the need for a TKA. Several biomaterial and cell-based therapies are currently in development and have shown early promise in both preclinical and clinical studies. The use of advanced biomaterials and stem cells independently or in conjunction to treat knee OA could potentially reduce pain and regenerate focal articular cartilage damage. In this review, we discuss the pathogenesis of pain and cartilage damage in knee OA and explore novel treatment options currently being studied, along with some of their limitations. |
format | Online Article Text |
id | pubmed-8986132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-89861322022-04-06 Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies Escobar Ivirico, Jorge L. Bhattacharjee, Maumita Kuyinu, Emmanuel Nair, Lakshmi S. Laurencin, Cato T. Engineering (Beijing) Article Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have been beneficial in treating the disease but none is as effective as total knee arthroplasty (TKA). However, while TKA is an end-stage solution of the disease, it is an invasive and expensive procedure. Therefore, innovative regenerative engineering strategies should be established as these could defer or annul the need for a TKA. Several biomaterial and cell-based therapies are currently in development and have shown early promise in both preclinical and clinical studies. The use of advanced biomaterials and stem cells independently or in conjunction to treat knee OA could potentially reduce pain and regenerate focal articular cartilage damage. In this review, we discuss the pathogenesis of pain and cartilage damage in knee OA and explore novel treatment options currently being studied, along with some of their limitations. 2017-02 2017-02-14 /pmc/articles/PMC8986132/ /pubmed/35392109 http://dx.doi.org/10.1016/j.eng.2017.01.003 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Escobar Ivirico, Jorge L. Bhattacharjee, Maumita Kuyinu, Emmanuel Nair, Lakshmi S. Laurencin, Cato T. Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title_full | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title_fullStr | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title_full_unstemmed | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title_short | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
title_sort | regenerative engineering for knee osteoarthritis treatment: biomaterials and cell-based technologies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986132/ https://www.ncbi.nlm.nih.gov/pubmed/35392109 http://dx.doi.org/10.1016/j.eng.2017.01.003 |
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