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Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Genetic optimization of Nucleic Acid immunogens is important for potentially improving their immune potency. A COVID-19 DNA vaccine is in phase III clinical trial which is based on a promising highly developable technology platform. Here, we show optimization in mice generating a pGX-9501 DNA vaccin...

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Detalles Bibliográficos
Autores principales:	Jiang, Sheng, Wu, Shuting, Zhao, Gan, He, Yue, Bao, Linlin, Liu, Jiangning, Qin, Chuan, Hou, Jiawang, Ding, Yuan, Cheng, Alex, Jiang, Brian, Wu, John, Yan, Jian, Humeau, Laurent, Patella, Ami, Weiner, David B., Broderick, Kate, Wang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Coronavirus – Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986195/ https://www.ncbi.nlm.nih.gov/pubmed/35061975 http://dx.doi.org/10.1080/21645515.2021.2016201

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