Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade

Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses...

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Autores principales: Sriram, Ganapathy, Emmons, Tiffany R., Milling, Lauren E., Irvine, Darrell J., Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986242/
https://www.ncbi.nlm.nih.gov/pubmed/35402699
http://dx.doi.org/10.1080/23723556.2022.2039038
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author Sriram, Ganapathy
Emmons, Tiffany R.
Milling, Lauren E.
Irvine, Darrell J.
Yaffe, Michael B.
author_facet Sriram, Ganapathy
Emmons, Tiffany R.
Milling, Lauren E.
Irvine, Darrell J.
Yaffe, Michael B.
author_sort Sriram, Ganapathy
collection PubMed
description Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses to systemic anti-PD1/CTLA4. Therapeutic tumor cell injury, rather than complete killing, in the tumor microenvironment may enhance efficacy of immunotherapy in various cancers.
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spelling pubmed-89862422022-04-07 Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade Sriram, Ganapathy Emmons, Tiffany R. Milling, Lauren E. Irvine, Darrell J. Yaffe, Michael B. Mol Cell Oncol Commentary Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses to systemic anti-PD1/CTLA4. Therapeutic tumor cell injury, rather than complete killing, in the tumor microenvironment may enhance efficacy of immunotherapy in various cancers. Taylor & Francis 2022-04-03 /pmc/articles/PMC8986242/ /pubmed/35402699 http://dx.doi.org/10.1080/23723556.2022.2039038 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Sriram, Ganapathy
Emmons, Tiffany R.
Milling, Lauren E.
Irvine, Darrell J.
Yaffe, Michael B.
Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title_full Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title_fullStr Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title_full_unstemmed Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title_short Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
title_sort immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986242/
https://www.ncbi.nlm.nih.gov/pubmed/35402699
http://dx.doi.org/10.1080/23723556.2022.2039038
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