Cargando…

The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review

Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which ap...

Descripción completa

Detalles Bibliográficos
Autores principales: Pace, Nikolai Paul, Mintoff, Dillon, Borg, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986338/
https://www.ncbi.nlm.nih.gov/pubmed/35401657
http://dx.doi.org/10.3389/fgene.2022.861241
_version_ 1784682523238858752
author Pace, Nikolai Paul
Mintoff, Dillon
Borg, Isabella
author_facet Pace, Nikolai Paul
Mintoff, Dillon
Borg, Isabella
author_sort Pace, Nikolai Paul
collection PubMed
description Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application.
format Online
Article
Text
id pubmed-8986338
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89863382022-04-07 The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella Front Genet Genetics Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8986338/ /pubmed/35401657 http://dx.doi.org/10.3389/fgene.2022.861241 Text en Copyright © 2022 Pace, Mintoff and Borg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Pace, Nikolai Paul
Mintoff, Dillon
Borg, Isabella
The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title_full The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title_fullStr The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title_full_unstemmed The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title_short The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
title_sort genomic architecture of hidradenitis suppurativa—a systematic review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986338/
https://www.ncbi.nlm.nih.gov/pubmed/35401657
http://dx.doi.org/10.3389/fgene.2022.861241
work_keys_str_mv AT pacenikolaipaul thegenomicarchitectureofhidradenitissuppurativaasystematicreview
AT mintoffdillon thegenomicarchitectureofhidradenitissuppurativaasystematicreview
AT borgisabella thegenomicarchitectureofhidradenitissuppurativaasystematicreview
AT pacenikolaipaul genomicarchitectureofhidradenitissuppurativaasystematicreview
AT mintoffdillon genomicarchitectureofhidradenitissuppurativaasystematicreview
AT borgisabella genomicarchitectureofhidradenitissuppurativaasystematicreview