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The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review
Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which ap...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986338/ https://www.ncbi.nlm.nih.gov/pubmed/35401657 http://dx.doi.org/10.3389/fgene.2022.861241 |
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author | Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella |
author_facet | Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella |
author_sort | Pace, Nikolai Paul |
collection | PubMed |
description | Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application. |
format | Online Article Text |
id | pubmed-8986338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89863382022-04-07 The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella Front Genet Genetics Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8986338/ /pubmed/35401657 http://dx.doi.org/10.3389/fgene.2022.861241 Text en Copyright © 2022 Pace, Mintoff and Borg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title | The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title_full | The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title_fullStr | The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title_full_unstemmed | The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title_short | The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review |
title_sort | genomic architecture of hidradenitis suppurativa—a systematic review |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986338/ https://www.ncbi.nlm.nih.gov/pubmed/35401657 http://dx.doi.org/10.3389/fgene.2022.861241 |
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